This material is soluble in ethanol at 50 mg/mL and water at 45 mg/mL. Stock solutions may be autoclaved or filter sterilized. The compound is light sensitive. Stock solutions should be stored protected from light in amber glass bottles and are stable for at least 6 months at 2 - 8°C.
C9754
Colchicina
≥95% (HPLC), powder, antimitotic agent
Sinonimo/i:
(S)-N-(5,6,7,9-tetraidro-1,2,3,10-tetrametossi-9-ossobenzo[a]eptalene-7-il)acetamide
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100 MG
20,70 €
500 MG
69,70 €
1 G
116,00 €
5 G
464,00 €
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Cambia visualizzazione
100 MG
20,70 €
500 MG
69,70 €
1 G
116,00 €
5 G
464,00 €
About This Item
Formula empirica (notazione di Hill):
C22H25NO6
Numero CAS:
Peso molecolare:
399.44
Beilstein:
2228813
Numero CE:
Numero MDL:
Codice UNSPSC:
12352200
ID PubChem:
NACRES:
NA.77
Nome del prodotto
Colchicina, ≥95% (HPLC), powder
Saggio
≥95% (HPLC)
Stato
powder
Colore
white to yellow
Punto di fusione
150-160 °C (dec.) (lit.)
Solubilità
ethanol: 50 mg/mL
Stringa SMILE
COC1=CC=C2C(=CC1=O)[C@H](CCc3cc(OC)c(OC)c(OC)c23)NC(C)=O
InChI
1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1
IAKHMKGGTNLKSZ-INIZCTEOSA-N
Informazioni sul gene
human ... ABCB1(5243) , CYP3A4(1576) , TUBA1A(7846) , TUBA1B(10376) , TUBA1C(84790) , TUBA3C(7278) , TUBA3E(112714) , TUBA4A(7277) , TUBB(203068) , TUBB1(81027) , TUBB2A(7280) , TUBB2B(347733) , TUBB3(10381) , TUBB4A(10382) , TUBB4B(10383) , TUBB6(84617) , TUBB8(347688)
mouse ... Abcb1a(18671) , Abcb1b(18669)
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Descrizione generale
Colchicine is a secondary metabolite,[1] which has anti-inflammatory properties.[2] It is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, Behçet disease, vasculitides and pericarditis. Colchicine inhibits cell division, intracellular vesicle motility, secretion of cytokines and chemokines.[2] It is implicated in leukocyte diapedesis and lysosomal degranulation. Colchicine also blocks fibroblast proliferation and collagen transport to extracellular space.[1]
Applicazioni
Azioni biochim/fisiol
Antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
Caratteristiche e vantaggi
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Stoccaggio e stabilità
This product in powdered format can be stored in room temperature. Colchicine powder will darken upon exposure to light. Colchicine solutions can be sterilized by autoclaving or filtration. Sterilized solutions are stable for at least six months if protected from light. No appreciable colchicine hydrolysis occurred in neutral and slightly alkaline (pH = 8.1) solutions after storage frozen for 2 months.
Avvertenze
Danger
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Acute Tox. 2 Oral - Muta. 1B
Codice della classe di stoccaggio
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Elenchi normativi
Forniamo informazioni su eventuali restrizioni prevalentemente per i prodotti chimici. Per altre tipologie di prodotto siamo in grado di fornire soltanto informazioni limitate. Nessuna segnalazione significa che nessuno dei componenti è citato in un elenco. È dovere dell’utilizzatore assicurarsi che il prodotto venga impiegato in maniera sicura e a norme di legge.
EU REACH Annex XVII (Restriction List)
CAS No.
Scegli una delle versioni più recenti:
Certificati d'analisi (COA)
Lot/Batch Number
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Articoli
Discover Bioactive Small Molecules for ADME/Tox
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How should this colchicine be dissolved to create a solution?
1 risposta-
Utile?
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What is the solubility of product C9754, Colchicine? Also, what is the solution stability of Colchicine?
1 risposta-
The solubility of Colchicine in DMSO is 426 mg/ml at 25 °C. It can also be dissolved in absolute ethanol (50 mg/ml), producing a clear to slightly hazy, yellow to yellow-green solution. However, this may require heat.
Regarding solution stability, Colchicine powder darkens upon exposure to light. Sterilized solutions remain stable for at least six months if shielded from light. No significant hydrolysis of colchicine occurred in neutral and slightly alkaline solutions after two months of frozen storage.
Utile?
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How should Colchicine be stored as a powder and when dissolved? At which temperature?
1 risposta-
This product in powdered format can be stored in room temperature. Colchicine powder will darken upon exposure to light. Colchicine solutions can be sterilized by autoclaving or filtration. Sterilized solutions are stable for at least six months if protected from light. No appreciable colchicine hydrolysis occurred in neutral and slightly alkaline (pH = 8.1) solutions after storage frozen for 2 months.
Utile?
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