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C9415

Sigma-Aldrich

Z-Arg-Arg-Pro-Phe-His-Sta-Ile-His-Nε-Boc-Lys methyl ester

≥85% (HPLC)

Sinonimo/i:

CGP-29287

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About This Item

Formula empirica (notazione di Hill):
C72H110N20O15
Numero CAS:
93287-54-8
Peso molecolare:
1495.77
Numero MDL:
MFCD00133577
Codice UNSPSC:
12352200
ID PubChem:
329775207

Saggio

≥85% (HPLC)

Forma fisica

solid

tecniche

ligand binding assay: suitable

Temperatura di conservazione

−20°C

Stringa SMILE

CC[C@H](C)[C@H](NC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)OCc4ccccc4)C(=O)N[C@@H](Cc5c[nH]cn5)C(=O)N[C@@H](CCCCNC(=O)OC(C)(C)C)C(=O)OC

InChI

1S/C72H110N20O15/c1-9-44(4)59(65(100)89-55(36-48-39-78-42-83-48)62(97)85-51(67(102)105-8)25-16-17-29-81-70(103)107-72(5,6)7)91-58(94)37-57(93)52(33-43(2)3)86-63(98)54(35-47-38-77-41-82-47)87-61(96)53(34-45-21-12-10-13-22-45)88-64(99)56-28-20-32-92(56)66(101)50(27-19-31-80-69(75)76)84-60(95)49(26-18-30-79-68(73)74)90-71(104)106-40-46-23-14-11-15-24-46/h10-15,21-24,38-39,41-44,49-57,59,93H,9,16-20,25-37,40H2,1-8H3,(H,77,82)(H,78,83)(H,81,103)(H,84,95)(H,85,97)(H,86,98)(H,87,96)(H,88,99)(H,89,100)(H,90,104)(H,91,94)(H4,73,74,79)(H4,75,76,80)/t44-,49-,50-,51-,52-,53-,54-,55-,56-,57-,59-/m0/s1
DLAHCJHYEAZDLE-VRYQDWSQSA-N

Azioni biochim/fisiol

Primate-specific renin inhibitor with prolonged duration of action.

Codice della classe di stoccaggio

13 - Non Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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J M Wood et al.
Clinical and experimental hypertension. Part A, Theory and practice, 9(2-3), 337-343 (1987-01-01)
The primate-specific renin inhibitor CGP 29287 (30 mg/kg/d, n = 5) or the converting-enzyme inhibitor CGS 14831 (30 mg/kg/d, n = 8) were administered by continuous intraperitoneal infusion via osmotic minipumps to normotensive marmosets fed a low salt diet. CGP
J M Wood et al.
Journal of hypertension, 7(8), 615-618 (1989-08-01)
The renin inhibitor CGP 29,287 was administered continuously for 7 days (30 mg/kg per day, intraperitoneally, via osmotic minipumps) to normotensive marmosets fed a low-salt diet. As a control, another group of marmosets was given vehicle only. After 7 days
K G Hofbauer et al.
Journal of cardiovascular pharmacology, 7 Suppl 4, S62-S68 (1985-01-01)
The hypotensive effects of inhibitors of renin or converting-enzyme (CE) were compared in normotensive sodium-depleted marmosets. Renin was inhibited by an antiserum or a monoclonal antibody against human kidney renin or by peptidic renin inhibitors. The fall in blood pressure
U Humke et al.
The American journal of physiology, 261(1 Pt 2), F179-F186 (1991-07-01)
A method for the measurement of renal clearances was adapted in a novel manner to the conscious marmoset. Twenty-four hours before an experiment, animals underwent surgery for placement of both femoral arterial and venous catheters. A catheter was also implanted
D Neisius et al.
The American journal of physiology, 251(5 Pt 2), H897-H902 (1986-11-01)
The relative importance of angiotensin II for the renal vasodilatory response after converting-enzyme inhibition was evaluated by a comparison of the effects of converting-enzyme and renin inhibition on renal vascular resistance. Renal, mesenteric, and hindquarter blood flows were measured with
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