C4382

Carbamoylcholine chloride

≥98% (titration), crystalline

• Sinonimo/i: (2-Hydroxyethyl)trimethylammonium chloride carbamate, Carbachol, Carbamylcholine chloride
• Formula condensata: NH₂COOCH₂CH₂N(Cl)(CH₃)₃
• Numero CAS: 51-83-2
• Peso molecolare: 182.65
• Beilstein: 3917459
• Numero CE: 200-127-3
• Numero MDL: MFCD00012011
• Codice UNSPSC: 12352200
• ID PubChem: 24277829
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (titration)
• Forma fisica: crystalline
• Colore: white
• Punto di fusione: 210 °C (dec.) (lit.)
• Solubilità: H₂O: 1 g/mL; ethanol: 20 mg/mL
• Stringa SMILE: [Cl-].C[N+](C)(C)CCOC(N)=O
• InChI: 1S/C6H14N2O2.ClH/c1-8(2,3)4-5-10-6(7)9;/h4-5H2,1-3H3,(H-,7,9);1H; AIXAANGOTKPUOY-UHFFFAOYSA-N
• Informazioni sul gene: human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131) , CHRM4(1132) , CHRM5(1133) , CHRNA2(1135) ; mouse ... Chrm1(12669) ; rat ... Chrm1(25229) , Chrm2(81645) , Chrm3(24260) , Chrna2(170945) , Chrna3(25101) , Chrna4(25590)

Descrizione

Applicazioni

Carbamoylcholine chloride has been used:

• to stimulate insulin secretion in transgenic mice
• to induce contraction of undifferentiated and differentiated human adipose-derived stem cells (hASCs)
• to mediate constriction of iris in pupillary light reflex studies in mice

Azioni biochim/fisiol

Carbachol elicits tear fluid secretion by interacting with muscarinic receptors. It is an analog of acetylcholine and an antiglaucoma drug. In ciliary processes, carbachol along with nitric oxide (NO) regulates Na⁺ and K⁺-ATPase activity. It stimulates insulin vesicles transport to the secretory site to increase insulin secretion.

Non-selective cholinergic agonist that is resistant to the action of cholinesterases; inhibits apoptotic death of cultured neurons, and may induce apoptosis in thymocytes.

Caratteristiche e vantaggi

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS06
• Avvertenze: Danger
• Indicazioni di pericolo: H300
• Consigli di prudenza: P264 - P270 - P301 + P310 - P405 - P501
• Classi di pericolo: Acute Tox. 2 Oral
• Codice della classe di stoccaggio: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges