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B4636

Sigma-Aldrich

Boc-Leu-Ser-Thr-Arg-7-amido-4-methylcoumarin

protein C substrate, ≥98% (HPLC), powder

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About This Item

Formula empirica (notazione di Hill):
C34H52N8O10
Numero CAS:
73554-93-5
Peso molecolare:
732.82
Numero MDL:
MFCD00080226
Codice UNSPSC:
12352204
ID PubChem:
24891793
NACRES:
NA.32

product name

Boc-Leu-Ser-Thr-Arg-7-amido-4-methylcoumarin, protein C substrate

Saggio

≥98% (HPLC)

Forma fisica

powder

Solubilità

ethanol: 2 mg/mL, clear, colorless

Temperatura di conservazione

−20°C

Stringa SMILE

CC(C)CC(NC(=O)OC(C)(C)C)C(=O)NC(CO)C(=O)NC(C(C)O)C(=O)NC(CCCNC(N)=N)C(=O)Nc1ccc2C(C)=CC(=O)Oc2c1

InChI

1S/C34H52N8O10/c1-17(2)13-23(41-33(50)52-34(5,6)7)29(47)40-24(16-43)30(48)42-27(19(4)44)31(49)39-22(9-8-12-37-32(35)36)28(46)38-20-10-11-21-18(3)14-26(45)51-25(21)15-20/h10-11,14-15,17,19,22-24,27,43-44H,8-9,12-13,16H2,1-7H3,(H,38,46)(H,39,49)(H,40,47)(H,41,50)(H,42,48)(H4,35,36,37)
ZJNWKMRGENOMCV-UHFFFAOYSA-N

Substrati

A fluorogenic substrate for activated protein C.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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H Sawada et al.
The Journal of experimental zoology, 254(1), 83-87 (1990-04-01)
Enzymatic properties of a protease involved in hatching of mouse embryos were examined. A trypsin-like protease, which most efficiently hydrolyzed t-butoxycarbonyl-Leu-Ser-Thr-Arg-4-methylcoumaryl-7-amide, was demonstrated in culture medium of mouse hatching embryos. The enzyme was strongly inhibited by diisopropyl fluorophosphate, phenylmethanesulfonyl fluoride
Brian T O'Neill et al.
The Journal of clinical investigation, 126(9), 3433-3446 (2016-08-16)
Diabetes strongly impacts protein metabolism, particularly in skeletal muscle. Insulin and IGF-1 enhance muscle protein synthesis through their receptors, but the relative roles of each in muscle proteostasis have not been fully elucidated. Using mice with muscle-specific deletion of the
Y Ohno et al.
Journal of biochemistry, 90(5), 1387-1395 (1981-11-01)
Protein C is a precursor of plasma serine proteinases, and its active form inactivates specifically blood coagulation Factor V and Factor VIII. Since a specific and sensitive synthetic substrate for the activated protein C was not known, we studied its
Ming Li et al.
Ecotoxicology and environmental safety, 135, 24-31 (2016-09-28)
Avermectins (AVMs) are used worldwide in agriculture and veterinary medicine. Residues of avermectin drugs, causing toxicological effects on non-target organisms, have raised great concern. The aim of this study was to investigate the effects of AVM on the expression levels
M A Nurseitova et al.
Journal of dairy science, 102(9), 7723-7733 (2019-07-01)
Milk fat adulteration is a common issue in Central Asia. To assess the current situation in the commercial milk market, 17 milk samples were checked for fatty acid (FA) and sterol profiles to detect potential adulteration using multivariate analysis. Analysis
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