For this product, the UniProt accession ID is P06276. A representative PDB structure for human butyrylcholinesterase is 1P0I.
B4186
Butyrylcholinesterase human
vial of ≥4 units
Sinonimo/i:
Acylcholine acyl-hydrolase, Choline esterase, butyryl, Pseudocholinesterase
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Cambia visualizzazione
| Voi/SKU | Disponibilità | Prezzo |
|---|---|---|
1 vial | Per informazioni sulla disponibilità, contatta il Servizio Clienti. | 831,00 € |
Informazioni su questo articolo
Numero CAS:
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
232-579-2
MDL number:
Numero CE:
Specific activity:
≥50 units/mg protein
831,00 €
Per informazioni sulla disponibilità, contatta il Servizio Clienti.
Servizio Tecnico
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Permettici di aiutartiApplication
BchE, from Sigma, has been used to determine butyrylcholinesterase inhibition by various test compounds .
Butyrylcholinesterase human has been used to study its role as a modulator of pathological features of Alzheimer′s disease (AD) in vivo.
Biochem/physiol Actions
Butyrylcholinesterase (BChE) is a serine hydrolase that shares substantial structural similarities with acetylcholinesterase (AchE) but has different substrate and inhibitor specificities. It is found in the serum, hemopoietic cells, liver, lung, heart and the central nervous system of vertebrates. BChE hydrolyzes large esters of choline such as butyrylcholine and benzoylcholine. Selective inhibition of BChE activity can be used in the detection of organophosphates. BchE may be used to treat organophosphate toxicity. It is a critical target for Alzheimer′s disease (AD) therapy.
Butyrylcholinesterase (BChE) is a serine hydrolase that shares substantial structural similarities with acetylcholinesterase (AchE) but has different substrate and inhibitor specificities. BChE is found in the serum, hemopoietic cells, liver, lung, heart and the central nervous system of vertebrates.
Analysis Note
Starting material individually donor tested and found negative for HIV I & II antibodies, Hepatitis B surfaceantigen, and Hepatitis C antibodies.
Other Notes
One unit will hydrolyze 1.0 μmole of butyrylcholine to choline and butyrate per min at pH 8.0 at 37 °C. The activity obtained using butyrylcholine as substrate is ~2.5 times that obtained using acetylcholine.
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Questo articolo | |||
|---|---|---|---|
| description vial of ≥4 units | description lyophilized powder, ≥500 units/mg protein | description lyophilized powder, ≥900 units/mg protein | description lyophilized powder, ≥10 units/mg protein |
| Gene Information human ... BCHE(590) | Gene Information - | Gene Information - | Gene Information - |
| specific activity ≥50 units/mg protein | specific activity ≥500 units/mg protein | specific activity ≥900 units/mg protein | specific activity ≥10 units/mg protein |
| form powder | form lyophilized powder | form lyophilized powder | form lyophilized powder |
| storage temp. 2-8°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| UniProt accession no. | UniProt accession no. - | UniProt accession no. - | UniProt accession no. - |
| Quality Level 200 | Quality Level 200 | Quality Level 300 | Quality Level 200 |
Parola di avvertenza
Danger
Codici di pericolo
Avvertenze di sicurezza
Hazard Classifications
Resp. Sens. 1
Classe di stoccaggio
11 - Combustible Solids
Che succede?
WGK 3
Punto di infiammabilità (°F)
Not applicable
Punto di infiammabilità (°C)
Not applicable
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Can you please provide the PDB or UNiprot Id of Butyrylcholinesterase
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What is the stability of Butyrylcholinesterase human vial of ≥4 units when stored at recommended temperature of 2-8C?
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This product is not assigned an expiration or retest date. Products that are robust in nature and extremely stable, in the original unopened container, are not assigned an expiration date or retest schedule. These products will have no dating reported on either the label or the Certificate of Analysis.
Products that are not assigned an expiration or retest date are covered by a warranty period of 1 year from the date of product shipment.
Full Product Dating Information may be reviewed at the link below: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/356/113/product-dating-information-06-25-ms.pdf
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How should Product B4186, Butyrylcholinesterase from human serum, be reconstituted?
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The enzyme can be reconstituted in 20 mM sodium phosphate buffer, pH 7.0, with 0.15 M sodium chloride.
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What amount of enzyme is present in 1 vial of Product B4186, Butyrylcholinesterase from human serum?
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Each vial will contain at least 5 units. The vial content is given on the certificate of analysis of each lot. The vial may be substantially overpacked.
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Are any buffer salts present in Product B4186, Butyrylcholinesterase from human serum?
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This product was lyophilized from 20 mM ammonium bicarbonate, which is a volatile buffer. So it would be expected to contain only traces of buffer salts.
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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