B2938

BEPP monohydrochloride

≥98% (HPLC), PKR activator, powder

• Sinonimo/i: 1H-Benzimidazole-1-ethanol, 2,3-dihydro-2-imino-alpha-(phenoxymethyl)-3-(phenylmethyl)- monohydrochloride
• Formula empirica (notazione di Hill): C₂₃H₂₃N₃O₂ HCl
• Numero CAS: 455311-98-5
• Peso molecolare: 409.91
• UNSPSC Code: 12352200
• PubChem Substance ID: 329773209
• NACRES: NA.77
• MDL number: MFCD00964481
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Proprietà

• Nome del prodotto: BEPP monohydrochloride, ≥98% (HPLC)
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to off-white
• solubility: DMSO: >10 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cl.OC(COc1ccccc1)CN2C(=N)N(Cc3ccccc3)c4ccccc24
• InChI: 1S/C23H23N3O2.ClH/c24-23-25(15-18-9-3-1-4-10-18)21-13-7-8-14-22(21)26(23)16-19(27)17-28-20-11-5-2-6-12-20;/h1-14,19,24,27H,15-17H2;1H
• InChI key: KDMXJFUGIDGZQL-UHFFFAOYSA-N

Descrizione

Biochem/physiol Actions

BEPP is a double-strand RNA-dependent protein kinase (PKR) activator.

BEPP is a double-strand RNA-dependent protein kinase (PKR) activator. The double-strand RNA (dsRNA)-dependent protein kinase is a ubiquitously expressed serine threonine kinase, inducible by interferon γ. PRK is involved in several curtail cellular regulations including phosphorylation of eIF2α (which leads to inhibition of protein synthesis and eliciting antivirus and antitumor activities), modulating activities of eIF2α, NF-κB, ATF-3, and p53. BEPP also inhibits the growth of a human lung cancer cell line overexpressing PKR.

Informazioni sulla sicurezza

• Classe di stoccaggio: 11 - Combustible Solids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable