A2979

A-317491 sodium salt hydrate

≥98% (HPLC), powder

• Sinonimo/i: 5-[[[(3-Phenoxyphenyl)methyl][(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]carbonyl]-1,2,4-benzenetricarboxylic acid sodium salt hydrate
• Formula empirica (notazione di Hill): C₃₃H₂₇NO₈ · xNa⁺ · yH₂O
• Peso molecolare: 565.57 (anhydrous free acid basis)
• Codice UNSPSC: 12352200
• ID PubChem: 329770806
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Forma fisica: powder
• Colore: white to beige
• Solubilità: H₂O: 15 mg/mL, clear
• Ideatore: Abbott
• Stringa SMILE: [Na].[H]O[H].OC(=O)c1cc(C(O)=O)c(cc1C(O)=O)C(=O)N(Cc2cccc(Oc3ccccc3)c2)[C@H]4CCCc5ccccc45
• InChI: 1S/C33H27NO8.Na.H2O.H/c35-30(25-17-27(32(38)39)28(33(40)41)18-26(25)31(36)37)34(29-15-7-10-21-9-4-5-14-24(21)29)19-20-8-6-13-23(16-20)42-22-11-2-1-3-12-22;;;/h1-6,8-9,11-14,16-18,29H,7,10,15,19H2,(H,36,37)(H,38,39)(H,40,41);;1H2;/t29-;;;/m0.../s1; VEMCGHRDAPMXLI-VYEUTZPBSA-N

Descrizione

Applicazioni

A-317491 sodium salt hydrate has been used to block the P2X3 receptor. It has also been used to block the increased membrane conductance.

Azioni biochim/fisiol

A-317491 helps to decrease neuropathic and inflammatory pain by inhibiting the P2X3 receptor-mediated Ca²⁺ influx.

Novel P2X₃ and P2X_2/3 receptor antagonist

Caratteristiche e vantaggi

This compound is featured on the P2 Receptors: P2X Ion Channel Family page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Note legali

Subject to U.S. Patent No. 6,831,193. Sold under license from Abbott Laboratories

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)