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Documenti

10942

Sigma-Aldrich

N-Butyryl-DL-homocysteine thiolactone

≥97.0% (HPLC)

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About This Item

Formula empirica (notazione di Hill):
C8H13NO2S
Numero CAS:
39837-08-6
Peso molecolare:
187.26
Numero MDL:
MFCD01862916
Codice UNSPSC:
12352200
eCl@ss:
32160406
ID PubChem:
57646863

Saggio

≥97.0% (HPLC)

Forma fisica

powder or crystals

Colore

white

Punto di fusione

76-80 °C

applicazioni

cell analysis

Temperatura di conservazione

2-8°C

Stringa SMILE

CCCC(=O)NC1CCSC1=O

InChI

1S/C8H13NO2S/c1-2-3-7(10)9-6-4-5-12-8(6)11/h6H,2-5H2,1H3,(H,9,10)
IMJUOGHALGXOSS-UHFFFAOYSA-N

Applicazioni

Application test: Induces violacein expression in a Chromobacterium violaceum mutant usually not able to produce homoserine lactones.

Azioni biochim/fisiol

N-Butyryl-DL-homocysteine thiolactone is a butylated derivative of homocysteine thiolactone which is used to induce hyperhomocysteinemia and seizures.

Codice della classe di stoccaggio

13 - Non Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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DL-Homocysteine ≥95% (titration)

Sigma-Aldrich

H4628

DL-Homocysteine

N V Zaichko
Ukrains'kyi biokhimichnyi zhurnal (1999 ), 82(2), 59-66 (2010-08-06)
Influence of DL-homocysteine thiolactone loading (100 mg/kg by intragastric administration for 28 days) on enzymes activity of adenylic nucleotide and adenosine metabolism in the blood serum, platelets and liver of rats was investigated. The relation between revealed disturbance and platelet
Claudia Roberta de Andrade et al.
Vascular pharmacology, 53(3-4), 99-106 (2010-05-11)
We aimed to investigate the vascular effects of hyperhomocysteinemia (HHcy) on carotid arteries from young and adult rats. With this purpose young and adult rats received a solution of DL-homocysteine-thiolactone (1 g/kg body weight/day) in the drinking water for 7
HYPERHOMOCYSTEINAEMIA-INDUCED CARDIOVASCULAR CHANGES IN RATS.
Resstel LB, de Andrade CR, et al.
Clinical and Experimental Pharmacology & Physiology, 35, 949-956 (2008)
Aleksandra Rašić Marković et al.
Cellular and molecular neurobiology, 31(8), 1221-1228 (2011-06-23)
Numerous studies have linked folate deficiency and resultant elevated plasma homocysteine levels with an increased risk of neurodegenerative diseases and seizures. The aim of the present study was to examine the effect of acute folic acid administration on behavioural and
K H McClean et al.
Microbiology (Reading, England), 143 ( Pt 12), 3703-3711 (1998-01-09)
Quorum sensing relies upon the interaction of a diffusible signal molecule with a transcriptional activator protein to couple gene expression with cell population density. In Gram-negative bacteria, such signal molecules are usually N-acylhomoserine lactones (AHLs) which differ in the structure

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