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940364

Sigma-Aldrich

GPhos Pd G4 ChemBeads

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Sinonimo/i:

Methanesulfonato[Dicyclohexyl[3-(1,1-dimethylethoxy)-6-methoxy-2′,6′-bis(1-methylethyl)[1,1′-biphenyl]-2-yl]phosphine](2′-methylamino-1,1′-biphenyl-2-yl)palladium(II) ChemBeads

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About This Item

Formula empirica (notazione di Hill):
C49H68NO5PPdS
Peso molecolare:
920.53
Codice UNSPSC:
12352100

Forma fisica

solid

Livello qualitativo

100

Composizione

, 4-6 wt. % (loading)

Impiego in reazioni chimiche

reagent type: catalyst

Stringa SMILE

COC(C(C1=C(C=CC=C1C(C)C)C(C)C)=C2[P](C3CCCCC3)([Pd]4(C5=C(C=CC=C5)C6=C(C=CC=C6)[NH]4C)OS(C)(=O)=O)C7CCCCC7)=CC=C2OC(C)(C)C

InChI

InChI=1S/C35H53O2P.C13H12N.CH4O3S.Pd/c1-24(2)28-20-15-21-29(25(3)4)32(28)33-30(36-8)22-23-31(37-35(5,6)7)34(33)38(26-16-11-9-12-17-26)27-18-13-10-14-19-27;1-14-13-10-6-5-9-12(13)11-7-3-2-4-8-11;1-5(2,3)4;/h15,20-27H,9-14,16-19H2,1-8H3;2-7,9-10,14H,1H3;1H3,(H,2,3,4);/q;;;+1/p-1
LJIBRSQNADCZDI-UHFFFAOYSA-M

Descrizione generale

The ChemBeads product of the GPhos ligand combined with the Buchwald Fourth Generation Palladacycle. The GPhos motif gives superb activity while having greater stability relative to other superbulky Buchwald ligands. Loaded at 5% wt. on glass beads for use in high-throughput expermentation (HTE).

Applicazioni

ChemBeads are chemical coated glass beads. ChemBeads offer improved flowability and chemical uniformity perfect for automated solid dispensing and high-throughput experimentation. The method of creating ChemBeads uses no other chemicals or surfactants allowing the user to accurately dispense sub-milligram amounts of chemical.

For general uses, product is also available in powdered form 920479

Caratteristiche e vantaggi

ChemBeads are chemical coated glass beads. ChemBeads offer improved flowability and chemical uniformity perfect for automated solid dispensing and high-throughput experimentation. The method of creating ChemBeads uses no other chemicals or surfactants allowing the user to accurately dispense sub-milligram amounts of chemical.

Prodotti correlati

N° Catalogo
Descrizione
Determinazione del prezzo

918008

GPhos, ≥95%

920479

GPhos Pd G4

920460

GPhos Pd G3

922900

GPhos Pd G6 TES

938750

GPhos ChemBeads

940356

GPhos Pd G3 ChemBeads

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

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Certificati d'analisi (COA)

Lot/Batch Number

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Scott D McCann et al.
Journal of the American Chemical Society, 142(35), 15027-15037 (2020-08-14)
We have developed a new dialkylbiaryl monophosphine ligand, GPhos, that supports a palladium catalyst capable of promoting carbon-nitrogen cross-coupling reactions between a variety of primary amines and aryl halides; in many cases, these reactions can be carried out at room
Bryan T Ingoglia et al.
Tetrahedron, 75(32), 4199-4211 (2020-01-04)
Over the past three decades, Pd-catalyzed cross-coupling reactions have become a mainstay of organic synthesis. In particular, catalysts derived from biaryl monophosphines have shown wide utility in forming C-N bonds under mild reaction conditions. This work summarizes a variety of
Noah P Tu et al.
Angewandte Chemie (International ed. in English), 58(24), 7987-7991 (2019-03-21)
Technologies that enable rapid screening of diverse reaction conditions are of critical importance to methodology development and reaction optimization, especially when molecules of high complexity and scarcity are involved. The lack of a general solid dispensing method for chemical reagents
Ana L Aguirre et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 27(51), 12981-12986 (2021-07-08)
High-throughput experimentation (HTE) methods are central to modern medicinal chemistry. While many HTE approaches to C-N and Csp2 -Csp2 bonds are available, options for Csp2 -Csp3 bonds are limited. We report here how the adaptation of nickel-catalyzed cross-electrophile coupling of

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