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Supelco

5′-Hydroxypiroxicam

VETRANAL®, analytical standard

Sinonimo/i:

4-Hydroxy-N-(5-hydroxy-2-pyridyl)-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide

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About This Item

Formula empirica (notazione di Hill):
C15H13N3O5S
Numero CAS:
77459-78-0
Peso molecolare:
347.35
Beilstein:
5142716
Numero MDL:
MFCD23136990
Codice UNSPSC:
41116107
ID PubChem:
329754054
NACRES:
NA.24

Grado

analytical standard

Livello qualitativo

100

Nome Commerciale

VETRANAL®

Durata

limited shelf life, expiry date on the label

tecniche

HPLC: suitable
gas chromatography (GC): suitable

applicazioni

forensics and toxicology
pharmaceutical (small molecule)

Formato

neat

Stringa SMILE

CN1C(C(=O)Nc2ccc(O)cn2)=C(O)c3ccccc3S1(=O)=O

InChI

1S/C15H13N3O5S/c1-18-13(15(21)17-12-7-6-9(19)8-16-12)14(20)10-4-2-3-5-11(10)24(18,22)23/h2-8,19-20H,1H3,(H,16,17,21)
CCKOORANQAQKKV-UHFFFAOYSA-N

Descrizione generale

5′-Hydroxypiroxicam (CAS:77459-78-0) belongs to the VETRANAL product line of high purity veterinary drug standards used for the determination of the active ingredients of the drug in processed food of animal origin.

Applicazioni

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Note legali

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H301

Classi di pericolo

Acute Tox. 3 Oral

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

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Certificati d'analisi (COA)

Lot/Batch Number

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A Klopas et al.
Journal of pharmaceutical and biomedical analysis, 17(3), 515-524 (1998-07-10)
A zero-crossing first-derivative spectrophotometric method for the determination of piroxicam and its major metabolite 5-hydroxypiroxicam (5-HP) in human plasma is described. This technique permits the quantification of compounds with closely overlapping spectral bands without any separation step. The method consists
High-performance liquid chromatographic analysis of piroxicam and its major metabolite 5'-hydroxypiroxicam in human plasma and urine.
C J Richardson et al.
Journal of chromatography, 382, 382-388 (1986-10-31)
V Ródenas et al.
The Analyst, 123(8), 1749-1752 (1999-03-11)
A first-derivative spectrophotometric method for the simultaneous determination of piroxicam (PX) and its major metabolite 5'-hydroxypiroxicam (OH PX) in human plasma is described. The method consists of direct extraction of the two drugs from the plasma samples with hydrochloric and
C J Richardson et al.
European journal of clinical pharmacology, 32(1), 89-91 (1987-01-01)
Piroxicam (20 mg once daily) was administered orally to six healthy young volunteers for 15 days. Trough steady-state levels of piroxicam and 5'-hydroxypiroxicam were 5.5 and 1.2 micrograms/ml, respectively. Piroxicam's plasma half-life (54.9 h) was significantly shorter than that of
P A Milligan
Journal of chromatography, 576(1), 121-128 (1992-04-15)
A simple and sensitive liquid chromatographic method with ultraviolet detection is described for the determination of the nonsteroidal anti-inflammatory drug piroxicam and its major metabolites in human plasma, urine and bile. Separation of these components occurs on a reversed phase
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