Passa al contenuto
Merck
Tutte le immagini(1)

Documenti fondamentali

PC420

Sigma-Aldrich

Anti-Capsaicin Receptor (Ab-1) (824-838) Rabbit pAb

liquid, Calbiochem®

Sinonimo/i:

Anti-Vanilloid Receptor

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali


About This Item

Codice UNSPSC:
12352203

Origine biologica

rabbit

Livello qualitativo

Forma dell’anticorpo

purified antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

liquid

contiene

≤0.1% sodium azide as preservative

Reattività contro le specie

rat, mouse

Produttore/marchio commerciale

Calbiochem®

Condizioni di stoccaggio

OK to freeze
avoid repeated freeze/thaw cycles

Isotipo

IgG

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

mouse ... Trpv1(193034)

Descrizione generale

Anti-Capsaicin Receptor (Ab-1) (824-838), rabbit polyclonal, recognizes the ~100 kDa capsaicin receptor in mouse spinal cord extract. It is validated for WB, IF & IHC in frozen and paraffin sections.
Protein A purified rabbit polyclonal antibody. Recognizes the ~100 kDa capsaicin receptor protein.
Recognizes the ~100 kDa capsaicin receptor protein in mouse spinal cord extract.

Immunogeno

a synthetic peptide (EDAEVFKDSMVPGEK) corresponding to amino acids 824-838 of rat capsaicin receptor, conjugated to KLH

Applicazioni



Frozen Sections (5 g/ml, see application references)
Immunoblotting (5-10 g/ml)
Immunofluorescence (2 g/ml)
Paraffin Sections (5 g/ml; no pre-treatment required)

Confezionamento

Please refer to vial label for lot-specific concentration.

Attenzione

Toxicity: Standard Handling (A)

Risultati analitici

Positive Control
Mouse spinal cord dorsal horn

Altre note

Caterina, M.J., et al. 1999. Nature398, 436.
Gau, A., et al. 1999. Eur. J. Neurosci.11, 946.
Michael, G.J., and Priestley, J.V. 1999. J. Neurosci.19, 1844.
Caterina, M.J., et al. 1997. Nature389, 816.
Szallasi, A. 1994. Gen. Pharmacol.25, 223.
Beven, S., and Szolcsanyi, J. 1990. Trends Pharmacol. Sci.11, 330.
Fields, H.L. 1987. Pain (New York: McGraw-Hill).
Immunohistochemistry was performed on mouse spinal cord sections fixed in 4% paraformaldehyde. Immunohistochemical staining results correlate well with other independent reports and in situ hybridization studies. Antibody should be titrated for optimal results in individual systems.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Non trovi il prodotto giusto?  

Prova il nostro Motore di ricerca dei prodotti.

Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

nwg

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

N J Spencer et al.
Neuroscience, 153(2), 518-534 (2008-04-09)
Rodents detect visceral pain in response to noxious levels of rectal distension. However, the mechanoreceptors that innervate the rectum and respond to noxious levels of rectal distension have not been identified. Here, we have identified the mechanoreceptors of capsaicin-sensitive rectal
Klaus Bielefeldt et al.
American journal of physiology. Gastrointestinal and liver physiology, 291(5), G987-G997 (2006-05-27)
Recent studies suggest that the capsaicin receptor [transient receptor potential vanilloid (TRPV)1] may play a role in visceral mechanosensation. To address the potential role of TRPV1 in vagal sensory neurons, we developed a new in vitro technique allowing us to
M Kawashima et al.
European journal of histochemistry : EJH, 56(2), e21-e21 (2012-06-13)
Transient receptor potential vanilloid subfamily member 1 (TRPV1) is activated by capsaicin, acid, and heat and mediates pain through peripheral nerves. In the tongue, TRPV1 expression has been reported also in the epithelium. This indicates a possibility that sensation is
Nathaniel A Jeske et al.
Pain, 146(3), 301-307 (2009-09-22)
Post-translational modifications on various receptor proteins have significant effects on receptor activation. For the Transient Receptor Potential family V type 1 (TRPV1) receptor, phosphorylation of certain serine/threonine amino acid residues sensitizes the receptor to activation by capsaicin and heat. Although
Chiao-Chi Chen et al.
Scientific reports, 9(1), 12348-12348 (2019-08-28)
Gout is one of the most painful disease conditions. The central mechanism of pain processing in this condition remains elusive. Cerebral blood volume (CBV) responses are faithful correlates of brain activity changes; the application of CBV-weighted functional magnetic resonance imaging

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.