MABN355

Anti-HAND2 Antibody, Clone 7D4.1

clone 7D4.1, from mouse

• Sinonimo/i: Heart- and neural crest derivatives-expressed protein 2, Class A basic helix-loop-helix protein 26, bHLHa26, Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2, dHAND
• Codice UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Proprietà

• Origine biologica: mouse
• Livello qualitativo: 100
• Forma dell’anticorpo: purified immunoglobulin
• Tipo di anticorpo: primary antibodies
• Clone: 7D4.1, monoclonal
• Reattività contro le specie: human, mouse
• tecniche: immunohistochemistry: suitable; western blot: suitable
• Isotipo: IgG1κ
• N° accesso NCBI: NP_068808
• N° accesso UniProt: P61296
• Condizioni di spedizione: wet ice
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... HAND2(9464)

Descrizione

Descrizione generale

Heart-and neural crest derivatives-expressed protein 2 , also known as Class A basic helix-loop-helix protein 26 (bHLHa26), or Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2 (dHAND), and encoded by the gene HAND2/BHLHA26/DHAND, is a transcription factor that is essential for cardiac morphogenesis, particularly the formation of the right ventricle and the aortic arch arteries. Heart-and neural crest derivatives-expressed protein 2 is required for vascular development, angiogenesis and for limb development acting upstream of sonic hedgehog in the induction of the limb bud. Additionally, Heart-and neural crest derivatives-expressed protein 2 is central to cardiac neural crest cell development and involved in outflow tract morphogenesis as well as the maintenance of the adult heart and in the negative regulation of cardiac muscle cell apoptosis. Heart-and neural crest derivatives-expressed protein 2 is localized to the nucleus. Heart-and neural crest derivatives-expressed protein 2 is expressed in developing heart, lung and vascular system.

Immunogeno

Epitope: C-terminus outside the bHLH domain

Recombinant protein corresponding to the C-terminus outside the bHLH domain of human HAND2.

Applicazioni

Detect HAND2 using this Anti-HAND2 Antibody, Clone 7D4.1 validated for use in western blotting & IHC.

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected HAND2 in human placenta tissue.

Qualità

Evaluated by Western Blotting in mouse heart tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected HAND2 in 10 µg of mouse heart tissue lysate.

Descrizione del bersaglio

~30 kDa observed

Stato fisico

Format: Purified

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable