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MABC1736

Sigma-Aldrich

Anti-CIDE-A Antibody, clone V62P1E3 B10

Sinonimo/i:

Cell death activator CIDE-A;Cell death-inducing DFFA-like effector A

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25 μG
140,00 €
100 μG
351,00 €

140,00 €


Spedizione prevista il19 febbraio 2025Dettagli


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Cambia visualizzazione
25 μG
140,00 €
100 μG
351,00 €

About This Item

Codice UNSPSC:
12352203
NACRES:
NA.43

140,00 €


Spedizione prevista il19 febbraio 2025Dettagli


Richiedi un ordine bulk

Origine biologica

mouse

Livello qualitativo

Coniugato

unconjugated

Forma dell’anticorpo

purified antibody

Tipo di anticorpo

primary antibodies

Clone

V62P1E3 B10, monoclonal

PM

calculated mol wt 24.69 kDa

Purificato mediante

using protein G

Reattività contro le specie

human

Confezionamento

antibody small pack of 100 μg

tecniche

ELISA: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: suitable

Isotipo

IgG1κ

Sequenza dell’epitopo

C-terminal

N° accesso ID proteina

N° accesso UniProt

Condizioni di spedizione

ambient

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... CIDEA(1149)

Categorie correlate

Descrizione generale

Cell death activator CIDE-A (UniProt: O60543; also known as Cell death-inducing DFFA-like effector A) is encoded by the CIDEA gene (Gene ID: 1149) in human. Three members of the CIDE family of proteins have been described in human CIDE-A, CIDE-B, and CIDE-C. They all contain a common N-terminal CIDE-N domain and a C-terminal CIDE-C domain. CIDE-A is a brown fat-associated protein that has been implicated in lipid and energy metabolism. Its expression has been reported in colon and normal breast tissue. It binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. It is shown to be enriched at lipid droplet contact sites and at focal contact sites between lipid droplets where it promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. It is reported to strongly promote triglyceride accumulation even in cell types that do not normally store large amounts of neutral lipid. Its expression levels in adipose tissue have been correlated with insulin sensitivity, which could be related to enhanced storage of triglyceride resulting in reduced levels of fatty acid levels in the circulation. CIDE-A is also reported to acts as a CCAAT Enhancer Binding Protein b (CEBPB) coactivator in mammary epithelial cells and controls the expression of CEBPB downstream target genes, such as ID2, IGF1, PRLR, SOCS1, SOCS3, XDH. Higher expression of CIDE-A has been reported in colorectal tumors compared to normal colonic mucosa. (Ref.: Alnabulsi, A., et al. (2019). Int. J. Cancer. 145(4);1138-1147; Puri, V., et al. (2008). Proc. Natl. Acad. Sci. USA. 105(22); 7833-7838).

Specificità

Clone V62P1E3 B10 is a mouse monoclonal antibody that detects human Cell death activator CIDE-A. It targets an epitope within 9 amino acids from the C-terminal region.

Immunogeno

Ovalbumin-conjugated linear peptide corresponding to 9 amino acids from the C-terminal region of human CIDE-A.

Applicazioni

Quality Control Testing

Evaluated by Immunohistochemistry (Paraffin) in human colon cancer tissue sections.

Immunohistochemistry (Paraffin) Analysis: A 1:50 dilution of this antibody detected CIDE-A in human colon cancer tissue sections.

Tested Applications


Western Blotting Analysis: A representative lot detected CIDE-A in Western Blotting applications (Alnabulsi, A., et al. (2019). Int J Cancer. 145(4):1138-1147).

ELISA Analysis: A representative lot detected CIDEA in ELISA applications (Alnabulsi, A., et al. (2019). Int J Cancer. 145(4):1138-1147).

Immunohistochemistry Applications: A representative lot detected CIDEA in Immunohistochemistry applications (Alnabulsi, A., et al. (2019). Int J Cancer. 145(4):1138-1147).

Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user
Anti-CIDE-A, clone V62P1E3 B10, Cat. No. MABC1736, is a mouse monoclonal antibody that detects CIDE-A and is tested for use in ELISA, Immunohistochemistry (Paraffin), and Western Blotting.

Stato fisico

Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stoccaggio e stabilità

Recommended storage: +2°C to +8°C.

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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