MAB2641

Anti-Fibrillin (Pan) Antibody, clone 689

clone 689, from mouse

• Sinonimo/i: EGF-containing fibulin-like extracellular matrix protein 1, Fibrillin-like protein, Extracellular protein S1-5
• Codice UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Proprietà

• Origine biologica: mouse
• Livello qualitativo: 100
• Forma dell’anticorpo: purified immunoglobulin
• Tipo di anticorpo: primary antibodies
• Clone: 689, monoclonal
• Reattività contro le specie: mouse
• Reattività contro le specie (prevista in base all’omologia): chicken (based on 100% sequence homology), human (based on 100% sequence homology)
• tecniche: ELISA: suitable; immunohistochemistry: suitable
• Isotipo: IgG1κ
• N° accesso NCBI: NP_115823
• N° accesso UniProt: Q75N90
• Condizioni di spedizione: wet ice
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... EFEMP1(2202)

Descrizione

Descrizione generale

Fibrillins are glycosolated and disulfide-rich components of the extracellular matrix belonging to the Fibrillin-LTBP protein family. They serve an important function in both nonelastic and elastic tissues such as eye, bone and blood vessels. The functional units of Fibrillin are known as microfibrils, multiprotein assemblies, which act as structural scaffolding for the limiting of the tissue elasticity, structural integrity of different organ systems, the assembly of elastic fibers, and regulation of BMP growth factor signaling. There are three known isoforms; Fibrillin 1, Fibrillin 2, and Fibrillin 3. Fibrillin 3 is the most recently described member of the Fibrillin family, with highest expression in the brain. Alterations in the microfibril assembly often occur in patients with fibrillinopathies such as; Congenital Contractual Arachnodactyly (CCA) which results in disruption of Fibrillin 2, and Marfan’s syndrome resulting from Fibrillin 1 mutation.

Specificità

The antibody recognizes isoforms 1, 2, and 3 of fibrillin.

Immunogeno

Recombinant protein corresponding to human Fibrillin 3.

Applicazioni

Anti-Fibrillin (Pan) Antibody, clone 689 detects level of Fibrillin (Pan) & has been published & validated for use in IH, ELISA.

ELISA Analysis: This antibody has been used by an independent laboratory in ELISA (Corson, 2003).

Qualità

Evaluated by Immunohistochemistry in fresh frozen mouse skin tissue.

Immunohistochemistry Analysis: 1:200 dilution of the antibody detected Fibrillin (Pan) in fresh frozen mouse skin tissue.

Descrizione del bersaglio

~ 350 kDa calculated

Stato fisico

Format: Purified

Risultati analitici

Control
Mouse skin tissue

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable