MAB1820

Anti-Scribble Antibody

clone 7C6.D10, Chemicon^®, from mouse

• Sinonimo/i: Scrib, LAP4
• Codice UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Proprietà

• Origine biologica: mouse
• Livello qualitativo: 100
• Forma dell’anticorpo: purified antibody
• Tipo di anticorpo: primary antibodies
• Clone: 7C6.D10, monoclonal
• Reattività contro le specie: human
• Produttore/marchio commerciale: Chemicon^®
• tecniche: western blot: suitable
• Isotipo: IgG1κ
• N° accesso Genebanck: AAL38976
• N° accesso UniProt: Q14160
• Condizioni di spedizione: wet ice
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... SCRIB(23513)

Descrizione

Descrizione generale

Scribble is a tumor suppressor marker first discovered in Drosophila that has been implicated in the control of cell proliferation, polarity, invasion, and metastasis (Humbert, et al, 2003). Mammalian Scribble expresses basolateral staining in epithelial tissue and highly polarized expression in T lymphocytes (Dow, et al, 2003) (Ludford-Menting, et al, 2005), and plays an essential role in the regulation of the polarity specifically involved in directed epithelial migration. Altered expression of human Scribble is associated with invasive epithelial cancers, however, its role in tumour development remains unclear (Dow, et al, 2007).

Specificità

Predicted to cross react with mouse based on sequence homology. Reactivity with other species has not been tested.

Immunogeno

Epitope: PDZ2 domain of Scribble

GST-tagged fusion protein corresponding to the PDZ2 domain of Scribble

Applicazioni

Suggested dilutions:
Western blot: 0.2 µg (1:2000)

Research Sub Category
Tumor Markers

Cytoskeleton

This Anti-Scribble Antibody is validated for use in WB for the detection of Scribble.

Qualità

Routinely evaluated by Western blot on HeLa cell lysates.

Descrizione del bersaglio

220 kDa

Stato fisico

Format: Purified

Purified in PBS containing with 0.05% NaN3.

Stoccaggio e stabilità

Maintain at 2-8°C for up to 1 year after date of receipt.

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Note legali

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

GenBank is a registered trademark of United States Department of Health and Human Services

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable