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MAB10050

Sigma-Aldrich

Anti-CCT-beta Antibody, clone F39 P7 F11

clone F39 P7 F11, Chemicon®, from mouse

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About This Item

Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Origine biologica

mouse

Livello qualitativo

Forma dell’anticorpo

purified immunoglobulin

Tipo di anticorpo

primary antibodies

Clone

F39 P7 F11, monoclonal

Reattività contro le specie

human

Produttore/marchio commerciale

Chemicon®

tecniche

immunohistochemistry: suitable
western blot: suitable

Isotipo

IgG2aκ

N° accesso NCBI

N° accesso UniProt

Condizioni di spedizione

wet ice

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... PCYT1B(9468)

Descrizione generale

This gene encodes a molecular chaperone that is member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of the gene described in this record have been observed but have not been thoroughly characterized.

Specificità

CCT-beta

Immunogeno

Synthetic Peptide corresponding to the C-Terminus of Human CCT-beta

Applicazioni

Research Category
Protein Trafficking
Research Sub Category
Chaperones
This Anti-CCT-beta Antibody, clone F39 P7 F11 is validated for use in WB for the detection of CCT-beta.
Western Blot Analysis: 0.1 - 0.5 ug/mL of this antibody detects a 60 kDa band of CCT-beta in HeLa cell lysate.

Optimal antibody dilution must be determined by end-user.

Descrizione del bersaglio

60 kDa

Stato fisico

Format: Purified
Protein A purified
Purified mouse monoclonal IgG2aκ in buffer containing PBS and 0.05% sodium azide.

Stoccaggio e stabilità

Stable for 1 year at 2-8°C from date of receipt.

Risultati analitici

Control
Tested on Hela cell lysate

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Note legali

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Heba Ghozlan et al.
Frontiers in oncology, 11, 663877-663877 (2021-05-18)
Uncontrolled proliferation as a result of dysregulated cell cycling is one of the hallmarks of cancer. Therapeutically targeting pathways that control the cell cycle would improve patient outcomes. However, the development of drug resistance and a limited number of inhibitors
Anne E Showalter et al.
Scientific reports, 10(1), 798-798 (2020-01-23)
Chaperonin-containing TCP-1 (CCT or TRiC) is a multi-subunit complex that folds many of the proteins essential for cancer development. CCT is expressed in diverse cancers and could be an ideal therapeutic target if not for the fact that the complex

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