676494

VEGF Inhibitor, Je-11 - Calbiochem

• Sinonimo/i: VEGF Inhibitor, Je-11 - Calbiochem, (RTELNVGIDFNWEYPAS)₂K-NH₂, VEGFR Tyrosine Kinase Inhibitor XI, VEGFR2 Kinase Inhibitor XII
• Formula empirica (notazione di Hill): C₁₈₈H₂₇₃N₄₉O₅₇
• Peso molecolare: 4131.47
• Codice UNSPSC: 12352200

Proprietà

• Saggio: ≥90% (HPLC)
• Livello qualitativo: 100
• Forma fisica: lyophilized solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; desiccated (hygroscopic)
• Colore: white
• Solubilità: DMSO: 5 mg/mL
• Condizioni di spedizione: ambient
• Temperatura di conservazione: 2-8°C

Descrizione

Descrizione generale

This product has been discontinued.

A dimerized peptide derived from the third Ig-like domain of the human vascular endothelial growth factor receptor-2 (VEGFR-2 or KDR/Flk-1) comprising residues 247 - 261. Acts as an inhibitor of VEGF-stimulated autophosphorylation of VEGFR-2 and inhibits the proliferation and migration of cultured microvascular endothelial cells. Binds to VEGF and blocks its interaction with VEGFR-2 (IC₅₀ = 500 nM on extracellular VEGFR-2 fragments; IC₅₀ = 30 µM on HUVEC).

A dimerized peptide derived from the third Ig-like domain of the human vascular endothelial growth factor receptor-2 (VEGFR-2 or KDR/FLK-1) comprising residues 247-261. Acts as an inhibitor of VEGF-stimulated autophosphorylation of VEGFR-2 (IC₅₀ = 500 nM on extracellular VEGFR-2 fragments; IC₅₀ = 30 µM on HUVEC).

Azioni biochim/fisiol

Cell permeable: no

Primary Target
Binds to VEGF and blocks its interaction with VEGFR-2

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 500 nM on extracellular VEGFR-2 fragments; 30 µM on HUVEC

Confezionamento

Packaged under inert gas

Attenzione

Toxicity: Standard Handling (A)

Sequenza

(H-Arg-Thr-Glu-Leu-Asn-Val-Gly-Ile-Asp-Phe-Asn-Trp-Glu-Tyr-Pro-Ala-Ser)₂-Lys-NH₂

Stato fisico

Supplied as a trifluoroacetate salt.

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Altre note

Piossek, C., et al. 1999. J. Biol. Chem.274, 5612.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10-13 - German Storage Class 10 to 13