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368050

Sigma-Aldrich

Granzyme B Inhibitor I

≥95% (HPLC), solid, Granzyme B inhibitor, Calbiochem®

Sinonimo/i:

Granzyme B Inhibitor I, Z-AAD-CMK

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About This Item

Formula empirica (notazione di Hill):
C19H24ClN3O7
Peso molecolare:
441.86
Codice UNSPSC:
12352200
NACRES:
NA.77

product name

Granzyme B Inhibitor I, The Granzyme B Inhibitor I controls the biological activity of Granzyme B. This small molecule/inhibitor is primarily used for Cancer applications.

Livello qualitativo

100

Saggio

≥95% (HPLC)

Forma fisica

solid

Produttore/marchio commerciale

Calbiochem®

Condizioni di stoccaggio

OK to freeze
desiccated

Colore

off-white

Solubilità

DMSO: 5 mg/mL

Condizioni di spedizione

ambient

Temperatura di conservazione

−20°C

Descrizione generale

A weak inhibitor of the human and murine granzyme B. Also inhibits the apoptosis-related DNA fragmentation in lymphocytes by fragmentin 2, a rat lymphocyte granule protease homologous to granzyme B (ID50 = 300 nM).
A weak inhibitor of the human and murine serine protease granzyme B. Also inhibits the apoptosis related DNA fragmentation in lymphocytes by fragmentin 2, a rat lymphocyte granule protease homologous to granzyme B (ID50 = 300 nM).

Azioni biochim/fisiol

Cell permeable: yes
Primary Target
Granzyme B
Product does not compete with ATP.
Reversible: no
Target IC50: 300 nM against the apoptosis-related DNA fragmentation in lymphocytes by fragmentin 2

Attenzione

Toxicity: Standard Handling (A)

Sequenza

Z-Ala-Ala-Asp-CH₂Cl

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Altre note

Gong, B., et al. 1999. Cell Growth Different. 10, 491.
Shi, L., et al. 1992. J. Exp. Med. 176, 1521.
Odake, S., et al. 1991. Biochemistry30, 2217.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Hippocampal neuronal apoptosis is a devastating consequence of cardiac arrest (CA) and subsequent cardiopulmonary resuscitation (CPR). In this study, we assessed the contribution of cytotoxic T lymphocyte (CTL)-derived toxic mediator granzyme B (Gra-b) to the hippocampal neuronal apoptosis following CA/CPR
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Penetration of immune cells into tumor cells was believed to be immune-suppressive via cell-in-cell (CIC) mediated death of the internalized immune cells. We unexpectedly found that CIC formation largely led to the death of the host tumor cells, but not
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Infiltration of leukocytes into post-ischemic cerebrum is a well-described phenomenon in stroke injury. Because CD-8(+) T-lymphocytes secrete cytotoxic proteases, including granzyme-b (Gra-b) that exacerbates post-ischemic brain damage, we investigated roles of Gra-b in human stroke. To study the role of

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