361562

GSK-3β Inhibitor XVIII

The GSK-3β Inhibitor XVIII, also referenced under CAS 1139875-74-3, controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Sinonimo/i: GSK-3β Inhibitor XVIII, 2-(Chloro-4-(4-thiophen-2-yl-pyrimidin-2-ylamino)-phenyl)-(4-methyl-pierazin-1-yl)-methanone
• Formula empirica (notazione di Hill): C₂₀H₂₀ClN₅OS
• Numero CAS: 1139875-74-3
• Peso molecolare: 413.92
• Codice UNSPSC: 12352200

Proprietà

• Livello qualitativo: 100
• Saggio: ≥97% (HPLC)
• Stato: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; protect from light
• Colore: white
• Solubilità: DMSO: 100 mg/mL
• Condizioni di spedizione: ambient
• Temperatura di conservazione: 2-8°C

Descrizione

Descrizione generale

A cell-permeable thienylpyrimidine compound that is reported to act as a potent and selective GSK-3β inhibitor (IC₅₀ = 64 nM), while exhibiting little or no activity against 58 and much reduced potency against 7 (>75% inhibition at 5 µM) other kinases. Shown to activate cellular Wnt pathway signaling (EC₅₀ = 1.25 µM in a Super (8X) TOPFlash reporter assay) in HEK293 cultures and promote proliferation of murine and hamster β cell lines (EC₅₀ = 1.143 µM using murine R7T1 cultures) as well as of primary rat β cells.

Confezionamento

Packaged under inert gas

Attenzione

Toxicity: Standard Handling (A)

Altre note

Wang, W., et al. 2009. Proc. Natl. Acad. Sci. USA106, 1427.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable