345744

Ganglioside GT_1b, Trisialo, Triammonium Salt, Bovine Brain

Inhibits Con A-stimulated mitogenesis in murine T cells.

• Sinonimo/i: Ganglioside GT_1b, Trisialo, Triammonium Salt, Bovine Brain, Neu5Acα2,3Galβ1,3GalNAcβ1,4(Neu5Acα2,8Neu5Acα2,3)Galβ1,4Glcβ1,1 Ceramide, 3NH₄
• Formula empirica (notazione di Hill): C₉₅H₁₆₂N₅O₄₇ · 3NH₄
• Peso molecolare: 2180.42
• Codice UNSPSC: 12352211
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (TLC)
• Forma fisica: lyophilized
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze
• Solubilità: ethanol: soluble; methanol: soluble
• Condizioni di spedizione: ambient
• Temperatura di conservazione: −20°C

Descrizione

Descrizione generale

Inhibits Con A-stimulated mitogenesis in murine T cells. Lymphocyte marker in cancer patients. Readily converted to GD_1b-disialoganglioside by bacterial and other mammalian neuraminidases without detergent or bile salts.

M.W. 2180.5 (based on stearoyl - 18:0).

Trisialoganglioside prepared from bovine gray matter. Readily converted to GD_1b-disialoganglioside by bacterial and mammalian sialidases without detergent or bile salts. Inhibits mitogenesis in concanavalin A-stimulated murine T-cells. Lymphocyte marker in cancer patients.



Note: This product is not to be used for animal treatment, in vivo research or in any other contact procedure with livestock.

Azioni biochim/fisiol

Cell permeable: no

Primary Target
Inhibits Con A-stimulated mitogenesis in murine T cells

Product does not compete with ATP.

Reversible: no

Attenzione

Toxicity: Irritant (B)

Nota sulla preparazione

For use in aqueous systems, dissolve in a small amount of ethanol and then sonicate in buffer or medium, or dissolve the dried sample directly in aqueous buffers by sonication. Solutions can be filter sterilized.

Ricostituzione

Following reconstitution, store in the refrigerator(4°C). Stock solutions are stable for up to 6 months at 4°C.

Altre note

Hakomori, S. 1985. Cancer Res.45, 2405.
Momoi, T., et al. 1976. Biochim. Biophys. Acta441, 488.
Warren, L. 1959. J. Biol. Chem.234, 1971.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable