344280

Fostriecin, Sodium Salt, Streptomyces pulveraceous - CAS 87860-39-7 - Calbiochem

An antitumor antibiotic that acts as a potent protein phosphatase 2A (PP2A) inhibitor (IC₅₀ = 3.2 nM).

• Sinonimo/i: Fostriecin, Sodium Salt, Streptomyces pulveraceous - CAS 87860-39-7 - Calbiochem, FST, Phosphotrienin
• Formula empirica (notazione di Hill): C₁₉H₂₆NaO₉P
• Numero CAS: 87860-39-7
• Peso molecolare: 452.37
• Numero MDL: MFCD09971059
• Codice UNSPSC: 12352200

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Stato: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; desiccated (hygroscopic); protect from light
• Colore: colorless
• Solubilità: ethanol: 10 mg/mL; methanol: 10 mg/mL; water: 50 mg/mL
• Condizioni di spedizione: ambient
• Temperatura di conservazione: −20°C

Descrizione

Descrizione generale

An antitumor antibiotic that acts as a potent protein phosphatase 2A (PP2A) inhibitor (IC₅₀ = 3.2 nM). Inhibits protein phosphatase 1 (PP1) at much higher concentrations (IC₅₀ = 131 µM). Does not affect the activity of protein phosphatase 2B (PP2B). Inhibits the catalytic activity of DNA topoisomerase II (topo II) and arrests cell growth at the G₂/M phase of the cell cycle in a dose-dependent manner.

Antitumor antibiotic that acts as a potent protein phosphatase 2A (PP2A) inhibitor (IC₅₀ = 3.2 nM). Also inhibits protein phosphatase 1 (PP1) at higher concentrations (IC₅₀ = 131 µM), but has no effect on protein phosphatase 2B (PP2B). Inhibits the catalytic activity of DNA topoisomerase II (topo II) and arrests cell growth at the G2/M phase of the cell cycle in a dose-dependent manner.

Azioni biochim/fisiol

Cell permeable: no

Primary Target
PP2a

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 3.2 nM, 131 µM, against protein phosphatase 2A (PP2A), protein phosphatase 1 (PP1), respectively

Confezionamento

Packaged under inert gas

Attenzione

Toxicity: Standard Handling (A)

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

Altre note

Cheng, A., et al. 1998. Cancer Res. 58, 3611.
Walsh, A.H., et al. 1997. FEBS Lett. 416, 230.
Boritzki, T.J., et al. 1988. Biochem. Pharmacol. 37, 4063.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable