C-017

(±)-Cotinine-d₃ solution

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• Sinonimo/i: (+/-)-Cotinine-d₃ solution
• Formula empirica (notazione di Hill): C₁₀H₉D₃N₂O
• Numero CAS: 110952-70-0
• Peso molecolare: 179.23
• Numero CE: 200-659-6
• Numero MDL: MFCD00083283
• Codice UNSPSC: 41116107
• ID PubChem: 329774766
• NACRES: NA.24

Proprietà

• Grado: certified reference material
• Forma fisica: liquid
• Caratteristiche: SNAP-N-SPIKE^®, SNAP-N-SHOOT^®
• Confezionamento: ampule of 1 mL
• Produttore/marchio commerciale: Cerilliant^®
• Concentrazione: 100 μg/mL in methanol
• tecniche: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• applicazioni: forensics and toxicology
• Formato: single component solution
• Temperatura di conservazione: −20°C
• InChI: 1S/C10H12N2O/c1-12-9(4-5-10(12)13)8-3-2-6-11-7-8/h2-3,6-7,9H,4-5H2,1H3/i1D3; UIKROCXWUNQSPJ-FIBGUPNXSA-N

Descrizione

Descrizione generale

Cotinine is an alkaloid found in tobacco as well as a major urinary metabolite of nicotine. This stable-labeled internal standard is suitable for quantitation of cotinine levels in urine, blood, and saliva for GC/MS or LC-MS/MS applications in nicotine testing or clinical and diagnostic testing of nicotine biomarkers.

Applicazioni

• Advanced mass spectrometry applications: A review covers high-performance liquid chromatography-mass spectrometry (HPLC-MS) methods, including the use of (±)-Cotinine-d₃ for the analysis of nicotine and its metabolite cotinine across various biological matrices, highlighting its role in accurate biomarker quantification (Jin et al., 2022).



• Exposure assessment in passive smoking: The study employs stable isotope dilution gas chromatography-triple quadrupole mass spectrometry with (±)-Cotinine-d₃ to determine urinary cotinine levels in children exposed to passive smoking, demonstrating its efficacy in environmental health research (Wang et al., 2014).



• Nicotine metabolism in special populations: Research utilizes a liquid chromatography-tandem mass spectrometry method to investigate nicotine metabolism in HIV-1-positive smokers, using (±)-Cotinine-d₃ to track metabolic variations, thereby aiding in personalized medicine approaches (Earla et al., 2014).



• Automated LC-MS-MS for cotinine detection: The development of an automated solid-phase extraction method for LC-MS-MS highlights the use of (±)-Cotinine-d₃ for streamlined and precise cotinine detection, applicable in clinical toxicology and therapeutic monitoring (Dunlop et al., 2014).



• Quantitative analysis in smoking cessation: A sensitive UPLC-tandem mass spectrometry procedure quantifies nicotine, cotinine, and their metabolites in plasma using (±)-Cotinine-d₃ as an internal standard, crucial for clinical studies on smoking cessation (Dobrinas et al., 2011).

Note legali

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Pittogrammi: GHS02,GHS06,GHS08
• Avvertenze: Danger
• Indicazioni di pericolo: H225,H301 + H311 + H331,H370
• Consigli di prudenza: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Classi di pericolo: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Organi bersaglio: Eyes
• Codice della classe di stoccaggio: 3 - Flammable liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): 49.5 °F - closed cup
• Punto d’infiammabilità (°C): 9.7 °C - closed cup