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911496

Sigma-Aldrich

Polyester bis-MPA dendron, 4 carboxyl, 1 Rhodamine (core)

generation 2

Sinonimo/i:

Bis-MPA dendron, Fluorescent linker, Fluoresent dendron

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About This Item

Formula empirica (notazione di Hill):
C67H87ClN2O28
Peso molecolare:
1403.86
Codice UNSPSC:
12162002
NACRES:
NA.23

Forma fisica

solid

PM

generation 2

N° gruppi superficiali

4

Colore

red to pink

Gruppo funzionale

(Rhodamine(core))

Temperatura di conservazione

−20°C

Categorie correlate

Descrizione generale

  • Polymer architecture: Dendron
  • End Group Functionality: Carboxyl
  • Bis-MPA: 2,2-Bis(hydroxymethyl)propionic acid

Applicazioni

Bis-MPA dendritic molecules are based on 2,2-bismethylolpropionicacid (bis-MPA) building blocks. The hydrolysable linkers presented in this type of polymers allow their degradation into byproducts that can be reabsorbed by the body or into excretable non-toxic small molecules. Therefore, this group of dendritic polymers is biocompatible and biodegradable, making them suitable for biomedical applications.
The corona of this product is functionalized by carboxyl groups, which can be readily used in bioconjugation. The rhodamine labeled core allows its application in bioimaging.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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Patrik Stenström et al.
Molecules (Basel, Switzerland), 23(8) (2018-08-17)
Herein, we present the first evaluation of cationic dendrimers based on 2,2-bis(methylol)propionic acid (bis-MPA) as nonviral vectors for transfection of short interfering RNA (siRNA) in cell cultures. The study encompassed dendrimers of generation one to four (G1⁻G4), modified to bear
Chemistry of multifunctional polymers based on bis-MPA and their cutting-edge applications.
Garcia-Gallego S, et al
Progress in Polymer Science, 48, 85-110 (2015)
Anna Carlmark et al.
Chemical Society reviews, 42(13), 5858-5879 (2013-05-01)
Dendritic polymers are highly branched, globular architectures with multiple representations of functional groups. These nanoscale organic frameworks continue to fascinate researchers worldwide and are today under intensive investigation in application-driven research. A large number of potential application areas have been

Articoli

Dendritic Polyester Scaffolds for Drug Delivery

Dendritic molecules' biomedical applications, particularly bis-MPA dendritic scaffolds, hold promise for drug delivery.

New Multi-Dendrimer Platforms for Supramolecular Assembly

Dendrimers, polymer nanostructures, are synthesized for specific purposes by manipulating critical nanoscale design parameters (CNDPs).

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