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765627

Sigma-Aldrich

Gold nanoparticles

10 nm diameter, methyl terminated, PEG 5000 coated, OD 50, dispersion in H2O

Sinonimo/i:

Gold nanoparticles OMe terminated, Au NP OMe, Gold Colloid

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About This Item

Codice UNSPSC:
12162002

Materiali

PEG 5000

Forma fisica

dispersion in H2O
nanoparticles

Confezionamento

poly bottle of 1 mL

OD

50

Diametro

10 nm

pH

6.0-8.0 (25 °C)

Solubilità

water: miscible

Densità

1.00 g/cm3

Gruppo funzionale

methoxy

Temperatura di conservazione

2-8°C

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Descrizione generale

Gold nanoparticles (AuNPs) ranging from 2-200nm in diameter find applications in diverse fields.They show excellent biocompatibility and attractive physicochemical properties. AuNPs, as aggregates, is shown to be highly sensitive colloidal biosensors. Poly (ethylene) glycol (PEG) surface coating on gold nanoparticles helps in the reduction of protein adsorption, reduces nonspecific interactions with cells and greatly improves the pharmokinetics of these nanoparticles and disables aggregation of the nanoparticles. AuNPs coated with PEG 5000 exhibited highest colloidal stability. The methyl group, being hydrophobic acts as a protecting shield between the gold nanoparticles and the hydrophilic outer PEG coating and also leads to a further reduction of protein adsorption and macrophage uptake by the AuNPs.

Applicazioni

Several other specific applications have been listed below:
  • Since they adhere to cell membranes, AuNPs may find use in cellular and intracellular targeting in targeted drug delivery applications and may also be used in biodistribution studies.
  • AuNPs may also be used in photothermal therapy and radiotherapy.
  • AuNPs ranging from 10 to 250 nm, were studied to have been absorbed primarily by liver and spleen , when injected intravenously in rats.Whereas, 10 nm nanoparticles were distributed more broadly into various organs.
Functionalized Particles have been extensively used to study cellular uptake of nanoparticles and targeted drug delivery.

Caratteristiche e vantaggi

PEG decreases the cytotoxicity and increases efficiency of GNPs in targeted drug delivery. PEG increases the stability of the nanoparticles and prevents agglomeration. Forms complexes easily with dyes and thiol ligands.

Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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Size-dependent in vivo toxicity of PEG-coated gold nanoparticles
Zhang, X. D., Wu, D., Shen, X., Liu, P. X., Yang, N., Zhao, B., & Fan, F. Y.
International journal of nanomedicine, 6, 2071j-2071j (2011)
Timothy A Larson et al.
ACS nano, 6(10), 9182-9190 (2012-09-27)
Polyethylene glycol (PEG) surface coatings are widely used to render stealth properties to nanoparticles in biological applications. There is abundant literature on the benefits of PEG coatings and their ability to reduce protein adsorption, to diminish nonspecific interactions with cells
Functionalized gold nanoparticles and their biomedical applications
Tiwari, P. M., Vig, K., Dennis, V. A., & Singh, S. R.
Nanomaterials, 1(1), 31-63 (2011)

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Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

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