Connexin 43 (Cx43) is also known as GJA1 (gap junction protein alpha 1) and belongs to a large family of homologous connexin proteins. This protein has an intracellular N-terminus, four transmembrane domains, two extracellular loops, one cytoplasmic loop and an intracellular C-terminus. It is located on human chromosome 6q22-q23.
Immunogen
The antiserum was produced against synthesized peptide derived from human Connexin 43 around the phosphorylation site of Ser368.
Immunogen Range: 332-381
Biochem/physiol Actions
Connexin 43 participates in the multiplication and differentiation of mature T cells. This protein also participates in the secretion and manufacturing of cytokines. Mutations in connexin 43 (Cx43) gene result in pleiotropic phenotype of oculodentodigital dysplasia. CX43 helps to release lactate from glycolytic pancreatic ductal adenocarcinoma cells.
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Molecular human reproduction, 25(10), 625-637 (2019-08-14)
Human blastocyst nidation in the uterus and successful pregnancy require coordinated endometrial expression of estrogen receptor (ER)-α, progesterone receptors (PR)-A and -B and the gap junction protein, connexin (Cx)43. Our prior work established that inflammation associated with conditions of reduced
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