SAB4200678

Anti-Collagen Type I antibody, Mouse monoclonal

clone COL-1, purified from hybridoma cell culture

• Synonym(s): Monoclonal Anti-Collagen Type I antibody produced in mouse, OI4, alpha 1, alpha 2, collagen, type I
• UNSPSC Code: 51111800
• NACRES: NA.41

Properties

• biological source: mouse
• Quality Level: 300
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: COL-1, monoclonal
• form: buffered aqueous solution
• species reactivity: pig, rat, human, deer, bovine
• concentration: ~1 mg/mL
• technique(s): ELISA: suitable; dot blot: suitable; immunoblotting: 1-2 μg/mL using recombinant human collagen, expressed in Nicotiana tabacum; immunohistochemistry: 3.5-7 μg/mL using frozen sections of human tonsil, human tongue or pig tongue
• isotype: IgG1
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... COL1A1(1277)

Description

General description

Collagen type Iα1 (COL1A1) is encoded by the gene that is located on human chromosome 17q21.33. It is the most abundant extracellular matrix (ECM) protein in humans. Type 1 collagen is the major structural protein of bone, tendon, skin and cornea. The encoded protein is a heterotrimer consisting of two α1-chains and one α2-chain.

Collagens are present in the extracellular matrix and contains a chains which can differ in length.

Immunogen

bovine skin collagen type I

Application

Monoclonal Anti-Collagen Type I antibody produced in mouse has been used in immunohistochemical analysis and in vitro invasion assays.

Biochem/physiol Actions

Collagen, type I (COL1A1) is an important component of the connective tissue matrix. It plays an important role in the growth and maintenance of organ and tissue integrity. This protein also participates in the process of tissue repair. COL1A1 is implicated in fibrosis.

Collagens are involved in structural roles. Additionally, they associate with various receptors and control cell proliferation, migration as well as differentiation.

Physical form

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable