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P9764

Sigma-Aldrich

Polydeoxyadenylic acid • Polythymidylic acid sodium salt

double-stranded homopolymer

Synonym(s):

Poly(dA) • Poly(dT)

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About This Item

CAS Number:
86834-22-2
MDL number:
MFCD00131963
UNSPSC Code:
41106305
NACRES:
NA.51

biological source

synthetic (organic)

Quality Level

200

form

powder

storage temp.

−20°C

InChI

1S/C10H14N5O6P.C10H15N2O8P/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(21-7)2-20-22(17,18)19;1-5-3-12(10(15)11-9(5)14)8-2-6(13)7(20-8)4-19-21(16,17)18/h3-7,16H,1-2H2,(H2,11,12,13)(H2,17,18,19);3,6-8,13H,2,4H2,1H3,(H,11,14,15)(H2,16,17,18)

InChI key

KKVQVIFXABFJCS-UHFFFAOYSA-N

Application

Polydeoxyadenylic acid • Polythymidylic acid (Poly(dA) • Poly(dT)) is a double-stranded homopolymer use as a DNA model for conformational studies of DNA structure dynamics and drug interaction.

Other Notes

Double-stranded homopolymer

Unit Definition

One unit will yield an A260 of 1.0 in 1.0 ml 20 mM sodium phosphate/100 mM NaCl, pH 7.0

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Yue Zhou et al.
BMC genomics, 5, 95-95 (2004-12-16)
DNA homopolymer tracts, poly(dA).poly(dT) and poly(dG).poly(dC), are the simplest of simple sequence repeats. Homopolymer tracts have been systematically examined in the coding, intron and flanking regions of a limited number of eukaryotes. As the number of DNA sequences publicly available
Hannah E J Polson et al.
Molecular and biochemical parasitology, 141(2), 179-189 (2005-04-27)
Expression of the Plasmodium falciparum calmodulin gene (pfcam) is developmentally regulated throughout the blood-stage cycle. The promoter lies within approximately 1 kb of intergenic sequence that separates the pfcam open reading frame (ORF) from an upstream inverted ORF encoding a
U Sehlstedt et al.
Journal of molecular biology, 278(1), 31-56 (1998-05-26)
The binding of an antiviral quinoxaline derivative, 2,3-dimethyl- 6 - (dimethylaminoethyl) - 9 - hydroxy - 6H - indolo - [2,3 - b]quinoxaline (9-OH-B220), to synthetic double and triple helical DNA (poly(dA).poly(dT) and poly(dA).2poly(dT)) and RNA (poly(rA). poly(rU) and poly
R Cao et al.
Journal of biomolecular structure & dynamics, 18(6), 844-856 (2001-07-11)
The DNA binding behavior of a tricationic cyanine dye (DiSC3+(5)) was studied using the [Poly(dA-dT)]2, [Poly(dI-dC)]2 and Poly(dA) x Poly(dT) duplex sequences and the Poly(dA) x 2Poly(dT) triplex. Optical spectroscopy and viscometry results indicate that the dye binds to the
Taegi Park et al.
Biochimica et biophysica acta, 1726(3), 287-292 (2005-09-01)
The binding modes of the free-base meso-tetrakis(N-methylpyridinium-4-yl)porphyrin (TMPyP) complexed with [d(AT)n]2 oligonucleotides (where n=3-8, corresponding to 6 to 16 AT base pairs) were studied by circular dichroism (CD). When associated with the shortest oligonucleotide, ([d(AT)3]2), a bisignate CD spectrum was
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