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P9528

Sigma-Aldrich

Polyuridylic acid potassium salt

Synonym(s):

Poly(U) potassium salt

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About This Item

CAS Number:
27416-86-0
MDL number:
MFCD00148052
UNSPSC Code:
41106305
NACRES:
NA.51

Assay

≥98% (TLC)

Quality Level

200

form

lyophilized powder

solubility

water: 19.60-20.40 mg/mL, clear to slightly hazy, colorless

storage temp.

−20°C

InChI

1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1

InChI key

DJJCXFVJDGTHFX-XVFCMESISA-N

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Application

Polyuridylic acid (Poly(U)), a homopolymer of uridine, is used as a single-stranded RNA model compound often in comparison with other ssRNA model oligonucleotides such as Poly(I) and Poly(C) to study processes that are dependent upon ssRNA regulation such as Toll-like receptor regulation. Poly(U) is used as an effective agonist for TLR7.

Preparation Note

Prepared from UDP using polynucleotide phosphorylase.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Yann Fichou et al.
Frontiers in neuroscience, 13, 1339-1339 (2020-01-11)
The aggregation of the human tau protein into neurofibrillary tangles is directly diagnostic of many neurodegenerative conditions termed tauopathies. The species, factors and events that are responsible for the initiation and propagation of tau aggregation are not clearly established, even
Debipreeta Bhowmik et al.
PloS one, 7(5), e37939-e37939 (2012-06-06)
Binding of two 9-O-(ω-amino) alkyl ether berberine analogs BC1 and BC2 to the RNA triplex poly(U)(•)poly(A)(*)poly(U) was studied by various biophysical techniques. Berberine analogs bind to the RNA triplex non-cooperatively. The affinity of binding was remarkably high by about 5
David R Strayer et al.
PloS one, 7(3), e31334-e31334 (2012-03-21)
Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a severely debilitating disease of unknown pathogenesis consisting of a variety of symptoms including severe fatigue. The objective of the study was to examine the efficacy and safety of a TLR-3 agonist, rintatolimod (Poly
Tiago Antonio de Souza et al.
PloS one, 7(2), e32305-e32305 (2012-03-03)
Plant pathogenic bacteria utilize an array of effector proteins to cause disease. Among them, transcriptional activator-like (TAL) effectors are unusual in the sense that they modulate transcription in the host. Although target genes and DNA specificity of TAL effectors have
Hirokazu Ishikawa et al.
RNA (New York, N.Y.), 18(5), 1062-1074 (2012-03-29)
Hfq-dependent sRNAs contain, at least, an mRNA base-pairing region, an Hfq-binding site, and a Rho-independent terminator. Recently, we found that the terminator poly(U) of Escherichia coli sRNAs is essential for Hfq binding and therefore for riboregulation. In this study, we
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