BTC is a selective estrogen receptor (ER) modulator (SERM) that acts as a selective estrogen mimic (SEM).
BTC is a selective estrogen receptor (ER) modulator (SERM) that acts as a selective estrogen mimic (SEM). BTC has been found to be both estrogenic and antiproliferative in ER-positive endocrine-resistant breast cancer cell lines that overexpress protein kinase C alpha (PKCα), which is often associated with tamoxifen resistance. BTC caused regression of endocrine-resistant breast cancer xenografts, and did not support the growth of hormone-dependent xenografts in vivo or cause an increase in uterine weight. As in the case with raloxifene and estradiol, BTC tumor regression was accompanied by the exit of ERα from the nucleus, suggesting extranuclear ERα may be involved in the mehanism of action.
Small (Weinheim an der Bergstrasse, Germany), 16(14), e1906276-e1906276 (2020-03-05)
Direct conversion of syngas to dimethyl ether (DME) through the intermediate of methanol allows more efficient DME production in a simpler reactor design relative to the conventional indirect route. Although Cu/ZnO-based multicomponent catalysts are highly active for methanol synthesis in
Journal of hazardous materials, 400, 123222-123222 (2020-06-27)
A convenient sensor is developed for electrochemical assay of Hg2+ in dairy product using the optimal Cu2+-based metal-organic frameworks (Cu-MOFs) as signal reporting. Benefiting from specific recognition between Hg2+ and thymine (T)-rich DNA strands, the interferences of milk matrices are
An efficient and simple metal-organic framework (MOF) assisted matrix solid-phase dispersion (MSPD) microextraction was developed for the extraction of the five saponins in P. ginseng leaves. The target analyses were detected by ultra high performance chromatography coupled with time-of-flight MS.
Journal of hazardous materials, 391, 121642-121642 (2020-02-12)
To enhance the photocatalytic activity of TiO2, a new preparation method has been proposed to synthesize the catalysts by introducing Cu-MOF as a precursor and performing a blackening process via a mixture with NaBH4 for TiO2 nanoparticles (CuO-TiO2(mb)). The results
Analytical and bioanalytical chemistry, 412(4), 849-860 (2020-01-04)
In this paper, a novel bimetallic Ce-Ni metal-organic frameworks (Ce-Ni-MOF) are synthesized by hydrothermal reaction, using 1,3,5-benzenetricarboxylic acid as a ligand. In particular, the bimetallic Ce-Ni-MOF with the largest specific surface area and catalytic sites was synthesized when the molar
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