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SAB2108741

Sigma-Aldrich

Anti-ZNF451

affinity isolated antibody

Synonym(s):

Anti- FLJ90693, Anti- KIAA0576, Anti- MGC26701, Anti- dJ417I1.1, Anti-COASTER

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

116 kDa

species reactivity

mouse, pig, horse, rat, human, dog

concentration

0.5-1 mg/mL

technique(s)

immunoblotting: suitable

accession no.

NM_015555

UniProt accession no.

Q9Y4E5

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ZNF451(26036)

Immunogen

Synthetic peptide directed towards the C terminal region of human ZNF451

Biochem/physiol Actions

ZNF451 belongs to the krueppel C2H2-type zinc-finger protein family and may be involved in transcriptional regulation.

Sequence

Synthetic peptide located within the following region: LLNSISDTTKECDSDDNMGAKNTSIGEEFISTEDVELEEAIRRSLEEM

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Giuseppina D'Alessandro et al.
Science advances, 9(49), eadl2108-eadl2108 (2023-12-06)
The catalytic cycle of topoisomerase 2 (TOP2) enzymes proceeds via a transient DNA double-strand break (DSB) intermediate termed the TOP2 cleavage complex (TOP2cc), in which the TOP2 protein is covalently bound to DNA. Anticancer agents such as etoposide operate by
Ka Cheong Lee et al.
International journal of molecular sciences, 19(7) (2018-07-18)
DNA topoisomerase II (TOP2) activity involves a normally transient double-strand break intermediate in which the enzyme is coupled to DNA via a 5'-phosphotyrosyl bond. However, etoposide and other topoisomerase drugs poison the enzyme by stabilising this enzyme-bridged break, resulting in
Ilan Theurillat et al.
Cell reports, 32(11), 108146-108146 (2020-09-17)
Post-translational modification by SUMO is a key regulator of cell identity. In mouse embryonic fibroblasts (MEFs), SUMO impedes reprogramming to pluripotency, while in embryonic stem cells (ESCs), it represses the emergence of totipotent-like cells, suggesting that SUMO targets distinct substrates
Nikoline Borgermann et al.
The EMBO journal, 38(8) (2019-03-28)
DNA-protein crosslinks (DPCs) are highly cytotoxic lesions that obstruct essential DNA transactions and whose resolution is critical for cell and organismal fitness. However, the mechanisms by which cells respond to and overcome DPCs remain incompletely understood. Recent studies unveiled a

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