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K2126

Sigma-Aldrich

β-Estradiol-6-one 6-(O-carboxymethyloxime)

≥98.00% (TLC), powder

Synonym(s):

β-Estradiol-6-(O-carboxymethyl)oxime, 1,3,5(10)-Estratriene-3,17β-diol-6-one6-(O-carboxymethyloxime), 3,17β-Dihydroxy-1,3,5(10)-estratriene 6-(O-carboxymethyl)oxime, 6-Ketoestradiol 6-(O-carboxymethyloxime)

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5 MG
₪938.00
50 MG
₪5,694.00

₪938.00

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5 MG
₪938.00
50 MG
₪5,694.00

About This Item

Empirical Formula (Hill Notation):
C20H25NO5
CAS Number:
35048-47-6
Molecular Weight:
359.42
Beilstein:
2484202
MDL number:
MFCD00056459
UNSPSC Code:
51111800
PubChem Substance ID:
329817132
NACRES:
NA.77

₪938.00

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Product Name

β-Estradiol-6-one 6-(O-carboxymethyloxime),

biological source

synthetic (organic)

Quality Level

200

Assay

≥98.00% (TLC)

form

powder

solubility

ethanol: 19.60-20.40 mg/mL, clear, colorless to faintly yellow

shipped in

ambient

storage temp.

2-8°C

SMILES string

C[C@]12CC[C@H]3[C@@H](C\C(=N\OCC(O)=O)c4cc(O)ccc34)[C@@H]1CC[C@@H]2O

InChI

1S/C20H25NO5/c1-20-7-6-13-12-3-2-11(22)8-15(12)17(21-26-10-19(24)25)9-14(13)16(20)4-5-18(20)23/h2-3,8,13-14,16,18,22-23H,4-7,9-10H2,1H3,(H,24,25)/b21-17-/t13-,14-,16+,18+,20+/m1/s1

InChI key

AWARIMYXKAIIGO-UYGYUSPXSA-N

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General description

β-Estradiol-6-one 6-(O-carboxymethyloxime) is a derivative of 17β-estradiol.[1]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000388379
0000365346
0000365345
0000365346
0000365345

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M Malawer et al.
Journal of surgical oncology, 25(3), 148-152 (1984-03-01)
Hormonal receptors of giant cell tumors (GCTs) have not been previously reported. Five cases of GCT of bone were analyzed for estrogen and progesterone binding. Frozen sections were studied by a histochemical method, using 17-beta-6-CMOBSA-FITC and 11-alpha-hydroxyprogesterone-HS-BSA-TMRITC. Cytoplasmic fluorescence with
C J Meijer et al.
Virchows Archiv. B, Cell pathology including molecular pathology, 40(1), 27-37 (1982-01-01)
The present study defines criteria for determining the presence of estrogen-receptors in human breast carcinomas demonstrated by a histochemical assay using 17 beta-estradiol-carboxy-methyl-oxim-bovine serum albumen-FITC. The criteria were: 1) the percentage of cells showing fluorescence; 2) the intensity of the
Markus Lacorn et al.
Journal of immunological methods, 297(1-2), 225-236 (2005-03-22)
17beta-estradiol (E2) concentrations are in the low pg/ml range in plasma. To develop a sensitive enzyme immunoassay (EIA) for E2-determination a highly specific antibody raised against a 6-carboxymethyl (CMO)-E2-bovine serum albumine conjugate was used. Based on 6-CMO-E2 and 6-amino-E2, four
R K Moats et al.
Biology of reproduction, 58(2), 531-538 (1998-02-25)
To investigate potential membrane-mediated responses to estrogen, a membrane-impermeant, radioiodinated, steroid-BSA conjugate--estradiol-17beta-6-(O-carboxymethyl)oxime:125I-labeled BSA (17beta-E-6-125I-BSA)--or related steroid conjugates, or 125I-BSA was injected into female Sprague-Dawley rats, and tissues were collected at varying times postinjection. The liver, adrenal, and spleen displayed the
K S McCarty et al.
Cancer, 46(12 Suppl), 2842-2845 (1980-12-15)
Three histochemical techniques for estrogen binding localization in tissue sections were compared to sucrose density gradient analyses for estrogen receptor in 186 breast carcinomas. Apparent localization to epithelial elements was noted using 6-BSA-Fluor-CMO-17 beta-estradiol, 17-BSA-Fluor-TSC-estrogen, and polyestradiol phosphate/anti-estradiol antibody methods.
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