G4386

γ-Globulins from human blood

≥99% (electrophoresis)

• Synonym(s): Human γ-Globulin
• CAS Number: 9007-83-4
• MDL number: MFCD00164089
• UNSPSC Code: 12352202
• NACRES: NA.61

Properties

• biological source: human blood
• Quality Level: 300
• Assay: ≥99% (electrophoresis)
• form: powder
• technique(s): protein quantification: suitable
• impurities: HIV, HCV and HBsAg, source material tested negative; ≤4% NaCl
• solubility: 0.9% NaCl: soluble 50 mg/mL
• UniProt accession no.: P15814
• storage temp.: 2-8°C
• Gene Information: human ... IGLL1(3543)

Description

General description

γ-Globulins are immunoglobulins and occur in five classes, namely: IgG, IgM, IgA, IgD, and IgE.[1] These are glycoproteins that are antibodies produced by plasma cells.[2] The immunoglobulins are heterogeneous molecules made up of four polypeptide chains (two light chains and two heavy chains) linked together by disulfide bonds.[3] The antigen-binding site is present at the nitrogen terminal.[3] 20% of the protein in plasma are immunoglobulins.[2]

Application

γ-Globulins from human blood have been used for the blocking step in cytometric bead array[4] It has also been used as a standard for γ-globulin measurement in cerebrospinal fluid (CSF).[5]

γ-globulins were used to study a micro-method for measuring total protein in cerebrospinal fluid by using benzethonium chloride in microtiter plate wells.[6] It was used in the measurement of protein in tannin-protein precipitates using ninhydrin. It was also used to study the blood distribution of levocetirizine, a new non-sedating histamine H1-receptor antagonist, in humans. [7]

Biochem/physiol Actions

Immunoglobulins are key regulators of the immune system and are produced in response to antigens. They protect our bodies against bacteria, viruses, and fungi. Immunoglobulins are involved in the activation of the complement system, opsonization of microbes for phagocytosis, neutralization of toxins and viruses, and inhibition of the attachment of microbes to mucosal surfaces. Immunodeficiency can lead to recurrent infectious diseases.[2]

Preparation Note

Prepared from Cohn Fraction II, III

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable