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Key Documents

SAB3500202

Sigma-Aldrich

Anti-SIRPα antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

Anti-SHPS-1, Anti-SIRPa

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About This Item

MDL number:
MFCD01634182
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

rat, mouse, human

technique(s)

immunocytochemistry: suitable
indirect ELISA: suitable
western blot: suitable

NCBI accession no.

NP_542970

UniProt accession no.

P78324

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... SIRPA(140885)

General description

Signal regulatory protein α (SIRPα) is expressed in dendritic cells and macrophages. It is a cell-surface protein. The protein possesses a highly glycosylated extracellular region, three immunoglobin superfamily domains and an intracellular domain with immunoreceptor tyrosine-based inhibitory motifs. The gene encoding SIRPα is localized on human chromosome 20p13.

Immunogen

SIRP alpha antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human SIRP alpha 1? The sequences of the immunogenic peptide differ from those of mouse, rat and bovine by one amino acid.

Biochem/physiol Actions

Signal regulatory protein α (SIRPα) acts as a modulator of immune responses. It has a role in the migration, adhesion, growth and differentiation of cells. SIRPα associates with cluster of differentiation 47 (CD47) and prevents phagocytosis by macrophages.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500202.

Physical form

Supplied in PBS with 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Pricing

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Engagement of SIRPα inhibits growth and induces programmed cell death in acute myeloid leukemia cells.
Irandoust M, et al.
PLoS ONE, 8(1), e52143-e52143 (2013)
On the origins of adaptive immunity: innate immune receptors join the tale.
van den Berg T K, et al.
Trends in Immunology, 25(1), 11-16 (2004)
Signal regulatory protein a associated with the progression of oral leukoplakia and oral squamous cell carcinoma regulates phenotype switch of macrophages.
Ye X, et al.
Oncotarget, 79(49), 81305-81305 (2016)

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