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58756

Sigma-Aldrich

1-(5-Isoquinolinesulfonyl)-3-methylpiperazine

≥98.0% (HPLC)

Synonym(s):

1-(5-Isoquinolinylsulfonyl)-3-methylpiperazine, Iso-H-7

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About This Item

Empirical Formula (Hill Notation):
C14H17N3O2S
CAS Number:
84477-73-6
Molecular Weight:
291.37
Beilstein:
5445506
MDL number:
MFCD00132900
UNSPSC Code:
12352202
PubChem Substance ID:
57651659
NACRES:
NA.77
Pricing and availability is not currently available.

Assay

≥98.0% (HPLC)

form

powder

storage temp.

2-8°C

SMILES string

CC1CN(CCN1)S(=O)(=O)c2cccc3cnccc23

InChI

1S/C14H17N3O2S/c1-11-10-17(8-7-16-11)20(18,19)14-4-2-3-12-9-15-6-5-13(12)14/h2-6,9,11,16H,7-8,10H2,1H3

InChI key

QGSCXAWTTISKLF-UHFFFAOYSA-N

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Biochem/physiol Actions

Less potent inhibitor of protein kinaseC than H-7

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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K Fujisawa et al.
Placenta, 21(4), 354-360 (2000-06-02)
To clarify the biological and pathological features of choriocarcinoma, we evaluated the in vitro production of cytokines by a choriocarcinoma cell line, BeWo. We measured the concentration of interleukin (IL)-6 and IL-8 in the culture media of BeWo cells after
C C Chua et al.
Biochimica et biophysica acta, 1401(2), 187-194 (1998-04-09)
Vascular endothelial growth factor (VEGF) is a potent mitogen for endothelial cells and a vascular permeability factor. In this study we found that the addition of angiotensin II (AII) to rat heart endothelial cells induced VEGF mRNA production. VEGF mRNA
J Duraj et al.
Neoplasma, 44(4), 205-211 (1997-01-01)
The human pre-B acute lymphoblastic leukemia cell line REH6 was utilized for characterization of CD45 glycoprotein by monoclonal antibodies (mAb) recognizing four distinct CD45 antigen specificities, i.e. nonrestricted CD45, restricted CD45RA, CD45RB and CD45R0. Immunoprecipitation revealed two antigen specificities on
Mei-Hua Li et al.
Zhonghua er bi yan hou ke za zhi, 39(6), 353-355 (2004-10-08)
To study the influence of the inhibitor of protein kinase C (PKC), Iso-H7 [1-(5-lsoquinolinyl-sulfony)-3-methylpiperazine dihydrochloride] on eosinophil apoptosis in nasal polyp tissues. Nasal polyp tissues were cultured and divided into two groups, test group (with Iso-H7 in different concentration) and
A Symes et al.
The Journal of biological chemistry, 272(15), 9648-9654 (1997-04-11)
Ciliary neurotrophic factor (CNTF)-dependent induction of expression of the neuropeptide vasoactive intestinal peptide (VIP) gene is mediated by a 180-base pair cytokine response element (CyRE) in the VIP promoter. To elucidate the molecular mechanisms mediating the transcriptional activation by CNTF
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