ekko™ Acoustic Cell Processing System
The ekko™ cell processing system is a true fit-for-purpose cell therapy manufacturing solution, employing acoustic technology and a multi-use platform to simplify cell therapy manufacturing. Its modular design improves flexibility and utilization while imparting minimal energy and stress for gentle handling of cells.
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Data Sheet: ekko™ Acoustic Cell Processing System
Concentration and wash
Whether you need to process an apheresis product or are harvesting from a bioreactor, the ekko™ system processes continuously without interruption. Flexible control allows for a wide range of inputs, final concentrations, yields, and processing times. This provides peace of mind, knowing that cell viability is maintained due to low-energy acoustic forces.
A variety of cell types can be processed, including:
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| Process Inputs | |
|---|---|
Volume | ≥120 mL |
Viable cell density | ≥0.75e6 T-cells/mL |
Total viable cells | ≥0.75e9 T-cells |
| Process outputs | |
Volume | ≥15 mL |
| Process performance | |
Viable cell recovery | 90% ± 5% |
Viability | <5% change |
Throughput | 3 L/hr + 10–30-minute wash and collection |
Wash residuals | >99% |
| |
Aggregate processing
The ekko™ system can be connected to your bioreactor of choice to enable a closed, integrated, and automated solution for your PSC aggregate expansion or differentiation process. The system is tunable to maximize single-cell removal or aggregate retention at each step, while gently minimizing cell residence time out of your bioreactor. Multiple unit operations can be performed, such as:
- Efficient media exchanges
- Gentle aggregate harvest
- Harvest of single cells
- Perfusion without need for filters
| Process Inputs | |
|---|---|
Volume | ≥120 mL |
Aggregate cell number | ≥1e8 aggregate cells |
| Process outputs | |
Volume | ≥15 mL |
| Process performance | |
Aggregate recovery | Tunable up to 99% |
Viability | <5% change |
Throughput | 4–6 L/hr |
Single cell depletion | Tunable up to 93% |
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