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D7017

Sigma-Aldrich

Dynorphin A Porcine Fragment 1-13

≥97% (HPLC)

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HUF 57,000.00

About This Item

Empirical Formula (Hill Notation):
C75H126N24O15
CAS Number:
72957-38-1
Molecular Weight:
1603.95
MDL number:
MFCD00076366
UNSPSC Code:
12352202
PubChem Substance ID:
24894071
NACRES:
NA.32

HUF 57,000.00

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Quality Level

200

Assay

≥97% (HPLC)

form

powder

composition

Peptide content, ≥50%

UniProt accession no.

P01214

storage temp.

−20°C

SMILES string

CCC(C)C(NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(C)C)NC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)C(N)Cc2ccc(O)cc2)C(=O)NC(CCCNC(N)=N)C(=O)N3CCCC3C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(O)=O

InChI

1S/C75H126N24O15/c1-7-45(6)61(70(111)94-53(25-17-35-87-75(83)84)71(112)99-36-18-26-58(99)69(110)93-50(21-11-13-31-76)64(105)96-56(38-44(4)5)67(108)95-54(72(113)114)22-12-14-32-77)98-65(106)52(24-16-34-86-74(81)82)91-63(104)51(23-15-33-85-73(79)80)92-66(107)55(37-43(2)3)97-68(109)57(40-46-19-9-8-10-20-46)90-60(102)42-88-59(101)41-89-62(103)49(78)39-47-27-29-48(100)30-28-47/h8-10,19-20,27-30,43-45,49-58,61,100H,7,11-18,21-26,31-42,76-78H2,1-6H3,(H,88,101)(H,89,103)(H,90,102)(H,91,104)(H,92,107)(H,93,110)(H,94,111)(H,95,108)(H,96,105)(H,97,109)(H,98,106)(H,113,114)(H4,79,80,85)(H4,81,82,86)(H4,83,84,87)

InChI key

OVVIBUHLQIYUEU-UHFFFAOYSA-N

Gene Information

pig ... PDYN(445529)

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Related Categories

Amino Acid Sequence

Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys

Application

Dynorphin A Porcine Fragment 1-13 has been used as a test compound in the field asymmetric waveform ion mobility spectrometry coupled to mass spectrometry (FAIMS/IMS/MS).[1]

Biochem/physiol Actions

Dynorphin (Dyn) (1-13), a bioactive product of dynorphin A[2] displays interaction with N-methyl- D-aspartate (NMDA) as well as with opioid receptors.[3] It elevates intracellular calcium [Ca2+]i level and contributes to the loss of neurons affecting neuronal viability.[2]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
SLCN5933
SLCJ5025
SLBV4020
SLBN9253V
SLBK8305V

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B Brugos et al.
Die Pharmazie, 59(5), 339-343 (2004-06-24)
Dynorphin A(1-13), a tridecapeptide of the endogenous opioid peptides, has modest effects in reducing mild opiate withdrawal in humans. Previous studies revealed that dynorphin also potentiates the analgesic effect of morphine in morphine-tolerant rats and mice. The therapeutic potential of
Mark S Wallace et al.
Journal of opioid management, 2(3), 167-173 (2007-02-27)
CJC-1008 is a chemical modification of the opioid peptide dynorphin A (1-13) (Dyn A) that promotes dynorphin's covalent attachment to human serum albumin in vivo after administration, thus prolonging its duration of action. The primary objective of this study was
Xin Sun et al.
Life sciences, 78(21), 2516-2522 (2005-12-13)
To investigate the relaxation effect and underlying mechanism of U50,488H (a selective kappa-opioid receptor agonist) in pulmonary artery in the rat. Isolated pulmonary artery ring was perfused and the tension of the vessel was measured. U50,488H relaxed the pulmonary artery
Sylvie Tordjman et al.
Behavior genetics, 33(5), 529-536 (2003-10-24)
Previous studies suggest that brain opioid activity decreases aggression in animal models. The main objective of the current study was to examine the possible genetic relationship between intermale aggression and brain levels of enkephalins, endorphins, and dynorphins in 11 inbred
Jing Liang et al.
Neuropharmacology, 58(1), 233-240 (2009-07-15)
Our previous studies have demonstrated that morphine-induced conditioned place preference (CPP) can be inhibited by 2 Hz electroacupuncture (EA). This inhibition can be blocked by either the opioid receptor antagonist naloxone (i.p.) or lesion in the nucleus accumbens (NAc), providing
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