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205273

Sigma-Aldrich

Titanium(IV) isopropoxide

97%

Synonym(s):

TTIP, Tetraisopropyl orthotitanate

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About This Item

Linear Formula:
Ti[OCH(CH3)2]4
CAS Number:
546-68-9
Molecular Weight:
284.22
Beilstein:
3679474
EC Number:
208-909-6
MDL number:
MFCD00008871
UNSPSC Code:
12352106
PubChem Substance ID:
24852318
NACRES:
NA.22
Pricing and availability is not currently available.

Quality Level

200

Assay

97%

form

liquid

reaction suitability

core: titanium
reagent type: catalyst

refractive index

n20/D 1.464 (lit.)

bp

232 °C (lit.)

mp

14-17 °C (lit.)

density

0.96 g/mL at 20 °C (lit.)

SMILES string

CC(C)O[Ti](OC(C)C)(OC(C)C)OC(C)C

InChI

1S/4C3H7O.Ti/c4*1-3(2)4;/h4*3H,1-2H3;/q4*-1;+4

InChI key

VXUYXOFXAQZZMF-UHFFFAOYSA-N

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General description

Titanium(IV) isopropoxide is a titanium-based coordination compound, commonly used in the asymmetric Sharpless epoxidation reaction of allylic alcohols. It is also used as a catalyst in Kulinkovich reaction for the synthesis of cyclopropanes.[1][2][3]

Application

Commonly used as a precursor for the preparation of Titania (TiO2)[4][5]
Novel metal oxide/phosphonate hybrids were formed from titanium(IV) isopropoxide in a two-step sol-gel process. Starting material for barium-strontium-titanate thin films. Used to make porous titanosilicates, potential ion-exchange materials for cleanup of radioactive wastes. Applied in the formation of a heterosupermolecule consisting of a TiO2 nanocrystallite-viologen electron acceptor complex whose light-induced electron transfer has been demonstrated.

Packaging

The 25 mL Sure/Seal™ bottle is recommended as a single-use bottle. Repeated punctures will likely result in decreased performance of product.

Legal Information

Product of Dorf Ketal
Sure/Seal is a trademark of Sigma-Aldrich Co. LLC

Pictograms

FlameExclamation mark
GHS02,GHS07

Signal Word

Warning

Hazard Statements

H226,H319,H336

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 3 - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

105.8 °F - Pensky-Martens closed cup

Flash Point(C)

41 °C - Pensky-Martens closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
STBL3921
SDBB1181
SDBB1179
SHBQ9968
STBK7606

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Titanium (IV) isopropoxide-catalyzed formation of 1-substituted cyclopropanols in the reaction of ethylmagnesium bromide with methyl alkanecarboxylates
Kulinkovich OG, et al.
Synthesis, 3, 234-234 (1991)
Ethers, Epoxides, and Sulfides
Organic Chemistry (2008)
Asymmetric epoxidation of allylic alcohols: the Katsuki-Sharpless epoxidation reaction
Katsuki T and Martin V
Organic Reactions, 48(3), 1-299 (2004)
Al-Jufairi, N.
Materials Science Forum, 517, 165-172 (2006)
J A Darr et al.
IEE proceedings. Nanobiotechnology, 152(3), 109-111 (2006-01-31)
Surfactant-coated amorphous titania nanospheres have been synthesised using templating 'water-in-supercritical carbon dioxide' emulsion droplets; the process represents a clean and controlled method for the manufacture of high-purity nanoparticles.
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Questions

1–9 of 9 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  3. Buongiorno, utilizziamo questo reagente per determinare la presenza di acqua nei solventi acquistati. Sapreste dirmi qual è la quantità minima di acqua che è possibile rilevare?

    1 answer

    1. While this material will react with water to form TiO2, the product is not specifically tested or used as a water scavenger. Unfortunately, there is no internal method or information available regarding this reaction. A brief search of the literature did not reveal any additional information.

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  4. What is the equivalent weight of ttip

    1 answer

    1. The equivalent weight of this product can be calculated by dividing the molecular weight by the net positive valence. It has 284.22 grams of Titanium(IV) isopropoxide per mole of titanium, and 71.055 grams of Titanium(IV) isopropoxide per mole of isopropoxide. The equivalent weight would depend on the source. That is, if you are looking at the material as a source of Titanium(IV), you would use 284.22 grams. But if they are looking at it as a source of the strong base (isopropoxide ion), you would use 71.055 grams. When looking at the Titanium(IV) isopropoxide per mole of titanium, there are +4 positively charged valence electrons which resulted 71.055 for the equivalent weight.

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  5. What is the difference between this and 87560 ttip?

    1 answer

    1. Products 205273 and 87560 have the same Chemical Abstract Service (CAS) number
      546-68-9, which means chemically they are the same substance. The difference between the two products are the product specifications. The product specification sheets for each product are linked below to facilitate a comparison for the specific application needs.

      https://www.sigmaaldrich.com/specification-sheet/ALDRICH/87560
      https://www.sigmaaldrich.com/specification-sheets/355/956/205273-BULK.pdf

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  6. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  7. What is the viscosity of Product 205273, Titanium (IV) Isopropoxide?

    1 answer

    1. The viscosity of titanium (IV) isopropoxide is 4.5 centipoise at 25 deg C.

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  8. What needs to be done if Product 205273, Titanium (IV) Isopropoxide is a solid instead of a liquid?

    1 answer

    1. The material will melt/freeze at 18-20 deg C, therefore the material can freeze when shipped during the winter months.  It can be warmed in a water bath to about 30 deg C to change the state without harming the chemical.

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  9. What is Product 205273, Titanium (IV) Isopropoxide soluble in?

    1 answer

    1. This chemical is very soluble in ethanol, carbon tetrachloride, hexane, benzene, or isopropanol.  Water is not recommended as a solvent because titanium (IV) isopropoxide will hydrolyze. (Precautions should be taken to make sure the solvents used do not contain any water - anhydrous grades would be recommended).

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