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Merck

1009005

USP

Acetylcysteine

United States Pharmacopeia (USP) Reference Standard

Sinónimos:

N-Acetyl-L-cysteine, LNAC, NAC

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About This Item

Fórmula lineal:
HSCH2CH(NHCOCH3)CO2H
Número de CAS:
Peso molecular:
163.19
Beilstein:
1724426
Número MDL:
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
NACRES:
NA.24

grado

pharmaceutical primary standard

familia API

acetylcysteine

fabricante / nombre comercial

USP

mp

106-108 °C (lit.)

aplicaciones

pharmaceutical (small molecule)

Formato

neat

temp. de almacenamiento

2-8°C

cadena SMILES

CC(=O)N[C@@H](CS)C(O)=O

InChI

1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)/t4-/m0/s1

Clave InChI

PWKSKIMOESPYIA-BYPYZUCNSA-N

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Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

Acetylcysteine USP reference standard intended for use in specified compendial tests and assays.

Also used to prepare standard stock and standard solution for assay by using the liquid chromatography method in conjunction with uv detector according to the given below monographs of United States Pharmacopeia (USP):
  • Acetylcysteine Solution
  • Acetylcysteine
  • Acetylcysteine Compounded Solution

Acciones bioquímicas o fisiológicas

Antioxidant and mucolytic agent. Increases cellular pools of free radical scavengers. Reported to prevent apoptosis in neuronal cells but induce apoptosis in smooth muscle cells. Inhibits HIV replication. May serve as a substrate for microsomal glutathione transferase.

Nota de análisis

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Otras notas

Sales restrictions may apply.

Pictogramas

Exclamation mark

Palabra de señalización

Warning

Frases de peligro

Clasificaciones de peligro

Eye Irrit. 2

Código de clase de almacenamiento

13 - Non Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Certificados de análisis (COA)

Lot/Batch Number

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Visite la Librería de documentos

Acetylcysteine Solution
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 27(3), 82-82 (2020)
Acetylcysteine
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 31(3), 82-82 (2020)
Acetylcysteine Compounded Solution
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 41(2), 83-83 (2020)
Eduesley Santana-Santos et al.
The Annals of thoracic surgery, 97(5), 1617-1623 (2014-03-25)
The renoprotective effect of N-acetylcystein in patients undergoing coronary artery bypass graft surgery is controversial. We assessed the renoprotective effect of the highest dose of N-acetylcystein sanctioned for clinical use in a prospective, double-blind, placebo-controlled study including 70 chronic kidney
Michael Berk et al.
Trends in pharmacological sciences, 34(3), 167-177 (2013-02-02)
N-Acetylcysteine (NAC) targets a diverse array of factors germane to the pathophysiology of multiple neuropsychiatric disorders including glutamatergic transmission, the antioxidant glutathione, neurotrophins, apoptosis, mitochondrial function, and inflammatory pathways. This review summarises the areas where the mechanisms of action of

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