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A7250

Sigma-Aldrich

N-Acetyl-L-cysteine

≥99% (TLC)

Sinónimos:

LNAC, NAC

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About This Item

Fórmula lineal:
HSCH2CH(NHCOCH3)CO2H
Número de CAS:
616-91-1
Peso molecular:
163.19
Beilstein:
1724426
Número CE:
210-498-3
Número MDL:
MFCD00004880
Código UNSPSC:
12352209
ID de la sustancia en PubChem:
24277970
NACRES:
NA.26
En este momento no podemos mostrarle ni los precios ni la disponibilidad

Nombre del producto

N-Acetyl-L-cysteine, Sigma Grade, ≥99% (TLC), powder

grado

Sigma Grade

Nivel de calidad

200

Ensayo

≥99% (TLC)

Formulario

powder

color

white to off-white

mp

106-108 °C (lit.)

solubilidad

H2O: 100 mg/mL (with heating)

aplicaciones

cell analysis

temp. de almacenamiento

2-8°C

cadena SMILES

CC(=O)N[C@@H](CS)C(O)=O

InChI

1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)/t4-/m0/s1

Clave InChI

PWKSKIMOESPYIA-BYPYZUCNSA-N

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Categorías relacionadas

Aplicación

N-Acetyl-L-cysteine has been used to suppress oxygen-dependent hydroxyurea sensitivity in Saccharomyces cerevisiae.[1] It has also been used as an antioxidant for the treatment of C2C12 murine myoblasts.[2]

Acciones bioquímicas o fisiológicas

Antioxidant and mucolytic agent. Increases cellular pools of free radical scavengers. Reported to prevent apoptosis in neuronal cells but induce apoptosis in smooth muscle cells. Inhibits HIV replication. May serve as a substrate for microsomal glutathione transferase.

Aplicación

Referencia del producto
Descripción
Precios

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Pictogramas

Exclamation mark
GHS07

Palabra de señalización

Warning

Frases de peligro

H319

Clasificaciones de peligro

Eye Irrit. 2

Código de clase de almacenamiento

13 - Non Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
0000429083
0000429083
0000423923
0000423923
WXBF4445V

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Loss of SOD1 and LYS7 Sensitizes Saccharomyces cerevisiae to Hydroxyurea and DNA Damage Agents and Downregulates MEC1 Pathway Effectors?
Carole D. Carter
Journal of Virology, 25(23), 10273-10285 (2005)
Low levels of lipopolysaccharide modulate mitochondrial oxygen consumption in skeletal muscle
Madlyn I. Frisard
Metabolism and Disease, 64(3), 416-427 (2015)
Carolina Martinez Romão et al.
Life sciences, 231, 116544-116544 (2019-06-11)
To investigate the effect of long-term N-acetyl-l-cysteine (NAC) treatment in Wistar rats subjected to renal ischemia and reperfusion (IR) and a chronic high‑sodium diet (HSD). Adult male Wistar rats received an HSD (8.0% NaCl) or a normal‑sodium diet (NSD; 1.3%
Suzanne M Cloonan et al.
Journal of medicinal chemistry, 58(11), 4494-4505 (2015-05-12)
Ruthenium polypyridyl complexes show great promise as new photodynamic therapy (PDT) agents. However, a lack of detailed understanding of their mode of action in cells poses a challenge to their development. We have designed a new Ru(II) PDT candidate that
Yuval Samuni et al.
Biochimica et biophysica acta, 1830(8), 4117-4129 (2013-04-27)
N-acetylcysteine (NAC) has been in clinical practice for several decades. It has been used as a mucolytic agent and for the treatment of numerous disorders including paracetamol intoxication, doxorubicin cardiotoxicity, ischemia-reperfusion cardiac injury, acute respiratory distress syndrome, bronchitis, chemotherapy-induced toxicity
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Chromatograms

application for HPLC

Questions

1–3 of 3 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. What information is available about the solubility and solution stability of A7250 N-Acetyl-L-cysteine?

    1 answer

    1. Solubility
      - N-acetyl-L-cysteine is soluble 1 in 8 of water and 1 in 2 of ethanol.
      - It is practically insoluble in chloroform and ether.
      - The solubility of product A7250 in water at 100 mg/mL was tested with heating and resulted in a clear, colorless solution.

      Solution Stability

      Aqueous stock solutions are stable for up to 1 month at -20°C. For N-acetyl-L-cysteine, the following information is relevant:
      - Aqueous solutions of cysteine oxidize to cystine upon exposure to air at neutral or alkaline pH.
      - Oxidation is hastened by traces of heavy metals, particularly copper and iron; however, it is relatively stable in an acidic environment.

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