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Z2625

Sigma-Aldrich

Zomepirac sodium salt

Sinónimos:

5-(p-Chlorobenzoyl)-1,4-dimethylpyrrole-2-acetic acid sodium-potassium salt

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About This Item

Fórmula lineal:
C15H13ClNO3Na
Número de CAS:
64092-48-4
Peso molecular:
313.71
Número CE:
264-669-2
Número MDL:
MFCD00057223
Código UNSPSC:
12161501
ID de la sustancia en PubChem:
24902176
NACRES:
NA.77

Nivel de calidad

200

cadena SMILES

Cc1cc(CC(=O)O[Na])n(C)c1C(=O)c2ccc(Cl)cc2

InChI

1S/C15H14ClNO3.Na/c1-9-7-12(8-13(18)19)17(2)14(9)15(20)10-3-5-11(16)6-4-10;/h3-7H,8H2,1-2H3,(H,18,19);/q;+1/p-1

Clave InChI

SEEXPXUCHVGZGU-UHFFFAOYSA-M

Aplicación

An NSAID. Circumvents MRP-mediated multidrug resistance. Significantly increases the cytotoxicity of the anthracyclines (doxorubicin, daunorubicin and epirubicin), as well as teniposide, VP-16 and vincristine.

Pictogramas

Skull and crossbones
GHS06

Palabra de señalización

Danger

Frases de peligro

H300,H311 + H331

Clasificaciones de peligro

Acute Tox. 2 Oral - Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation

Código de clase de almacenamiento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificados de análisis (COA)

Lot/Batch Number
0000274405
116H0298
082H0250
062F0466
013H0228

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Jørgen Olsen et al.
Chemical research in toxicology, 18(11), 1729-1736 (2005-11-23)
Zomepirac [ZP, 5-(chlorobenzoyl)-1,4-dimethylpyrrole-2-acetic acid] was withdrawn from the market because of unpredictable allergic reactions that may have been caused by ZP-protein adducts formed by reaction of the reactive acyl glucuronide of ZP (ZP-O-G) with endogenous proteins. To test the hypothesis
M J Bailey et al.
Journal of pharmacological and toxicological methods, 41(1), 27-32 (1999-10-03)
The covalent binding of drugs or their metabolites to proteins is of increasing interest in the investigation of the toxicity of these compounds. Recent attention on biological consequences of protein adduct formation with carboxylate drugs, derived via their reactive acyl
J Abraham
Social science & medicine (1982), 46(1), 39-51 (1998-02-17)
This article systematically examines government regulation of medicines in the U.K. and the U.S. with specific reference to carcinogenic risk assessment. By taking four non-steroidal anti-inflammatory drugs (NSAIDs) as case studies, it is argued that there have been inconsistencies between
M J Bailey et al.
Chemical research in toxicology, 9(3), 659-666 (1996-04-01)
Carboxylate drugs usually form acyl glucuronide conjugates as major metabolites. These electrophilic metabolites are reactive, capable of undergoing hydrolysis, rearrangement, and covalent binding reactions to proteins. The last-mentioned property has the potential to initiate immune and other toxic responses in
G R Cannell et al.
Life sciences, 70(1), 37-48 (2002-01-05)
Many nonsteroidal anti-inflammatory drugs (NSAIDs) which have antiproliferative activity in colon cancer cells are carboxylate compounds forming acyl glucuronide metabolites. Acyl glucuronides are potentially reactive, able to hydrolyse, rearrange into isomers, and covalently modify proteins under physiological conditions. This study
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