W102

(R)-(+)-WIN 55,212-2 mesylate salt

≥98% (HPLC), powder, CB2 agonist

• Sinónimos: WIN552122 mesylate
• Fórmula lineal: C₂₇H₂₆N₂O₃ · CH₃SO₃H
• Número de CAS: 131543-23-2
• Peso molecular: 522.61
• Número MDL: MFCD00153882
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24278779
• NACRES: NA.77

Propiedades

• Nombre del producto: (R)-(+)-WIN 55,212-2 mesylate salt, ≥98% (HPLC)
• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• control farmacológico: regulated under CDSA - not available from Sigma-Aldrich Canada
• color: white to beige
• solubilidad: 0.1 M HCl: 0.25 mg/mL; DMSO: 12 mg/mL; 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 2.4 mg/mL; 0.1 M NaOH: insoluble; H₂O: insoluble
• cadena SMILES: CS(O)(=O)=O.Cc1c(C(=O)c2cccc3ccccc23)c4cccc5OC[C@@H](CN6CCOCC6)n1c45
• InChI: 1S/C27H26N2O3.CH4O3S/c1-18-25(27(30)22-9-4-7-19-6-2-3-8-21(19)22)23-10-5-11-24-26(23)29(18)20(17-32-24)16-28-12-14-31-15-13-28;1-5(2,3)4/h2-11,20H,12-17H2,1H3;1H3,(H,2,3,4)/t20-;/m1./s1
• Clave InChI: FSGCSTPOPBJYSX-VEIFNGETSA-N
• Información sobre el gen: human ... CNR1(1268) , CNR2(1269)

Descripción

Descripción general

WIN 55,212-2 is a member of the aminoalkylindole class of compounds.

Aplicación

(R)-(+)-WIN 55,212-2 mesylate salt has been used as a high affinity cannabinoid agonist for intraperitoneal injection into rats to induce behavioural sensitization. It has also been used as a synthetic cannabinoid drug and cannabinoid receptor 1 (CNR1) agonist to treat Becn2+/− mice and wild-type (WT) littermate to analyze the levels of CNR1 in the brain.

Acciones bioquímicas o fisiológicas

It is known to decrease the lipopolysaccharide mediated release of tumor necrosis factor- α and interleukin-1 in mice.

Características y beneficios

This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Nota de preparación

The solubility of this chemical in DMF has not been determined. However, various sources state this chemical can be solubilized in about 30 mg/ml of DMF.

Información legal

Sold with the permission of Sterling-Winthrop, Inc.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)