V3639

Valinomycin

Ready Made Solution, ~1 mg/mL in DMSO

• Sinónimos: Cyclo(L-Val-D-HyIva-D-Val-L-Lac-)₃: HyIva = α-Hydroxyisovaleric acid, Lac = Lactic acid
• Fórmula empírica (notación de Hill): C₅₄H₉₀N₆O₁₈
• Número de CAS: 2001-95-8
• Peso molecular: 1111.32
• Beilstein: 78657
• Número MDL: MFCD00005114
• Código UNSPSC: 51102829
• ID de la sustancia en PubChem: 24900743
• NACRES: NA.76

Propiedades

• origen biológico: Streptomyces sp.
• Nivel de calidad: 200
• Ensayo: ≥90% (HPLC)
• Formulario: liquid
• condiciones de almacenamiento: (Keep container tightly closed in a dry and well-ventilated place. Hydroscopic.)
• concentración: ~1 mg/mL in DMSO
• color: colorless
• espectro de actividad antibiótica: Gram-positive bacteria; parasites; viruses
• Modo de acción: cell membrane | interferes
• Condiciones de envío: wet ice
• temp. de almacenamiento: 2-8°C
• cadena SMILES: CC(C)[C@@H]1NC(=O)[C@H](C)OC(=O)[C@@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC1=O)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C
• InChI: 1S/C54H90N6O18/c1-22(2)34-49(67)73-31(19)43(61)55-38(26(9)10)53(71)77-41(29(15)16)47(65)59-36(24(5)6)51(69)75-33(21)45(63)57-39(27(11)12)54(72)78-42(30(17)18)48(66)60-35(23(3)4)50(68)74-32(20)44(62)56-37(25(7)8)52(70)76-40(28(13)14)46(64)58-34/h22-42H,1-21H3,(H,55,61)(H,56,62)(H,57,63)(H,58,64)(H,59,65)(H,60,66)/t31-,32-,33-,34-,35+,36+,37-,38-,39-,40+,41+,42+/m0/s1
• Clave InChI: FCFNRCROJUBPLU-RPUZOQEISA-N

Descripción

Descripción general

Chemical structure: peptide

Aplicación

Valinomycin is a cyclic dodecadepsipeptides with potassium ionophoric properties. It is used to study ion transport in biological systems. It is used to study its inhibitory effect on intact cells and the growth of bacteria and yeast. It is used to induce apoptosis.

Acciones bioquímicas o fisiológicas

K⁺-selective ionophore which uncouples oxidative phosphorylation.

K⁺-selective ionophoric cyclodepsipeptide; potassium ionophore which uncouples oxidative phosphorylation, induces apoptosis in murine thymocytes, inhibits NGF-induced neuronal differentiation and antagonizes ET-induced vasoconstriction.

Valinomycin is a K+-selective ionophoric cyclodepsipeptide. It is a potassium ionophore which uncouples oxidative phosphorylation, induces apoptosis in murine thymocytes, inhibits NGF-induced neuronal differentiation and antagonizes ET-induced vasoconstriction. It is reported to be insecticidal, nematicidal and antiviral.

Otras notas

Keep container tightly closed in a dry and well-ventilated place. Hygroscopic.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): 188.6 °F - closed cup
• Punto de inflamabilidad (°C): 87 °C - closed cup
• Equipo de protección personal: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter