SRP6323
Pentraxin 3 human
recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
Sinónimos:
PTX3, TNFAIP5, TSG-14
Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
About This Item
UNSPSC Code:
12352200
NACRES:
NA.32
Productos recomendados
biological source
human
recombinant
expressed in E. coli
assay
≥90% (SDS-PAGE)
form
liquid
mol wt
44.4 kDa (401 aa, 18-381 aa + His Tag)
packaging
pkg of 100 μg
concentration
1 mg/mL
impurities
<1 EU/μg endotoxin (LAL test)
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... PTX3(5806)
General description
Pentraxin 3 (PTX3) or tumor necrosis factor (TNF)-stimulated gene is the prototypic member of the long pentraxin family sharing the C-terminal domain with short pentraxins and containing a unique N-terminal domain. The gene encoding this protein is localized on human chromosome 3q25.32 and consists of 3 exons. Recombinant human Pentraxin 3 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
Biochem/physiol Actions
Pentraxin 3 (PTX3) is an acute phase protein produced and released at inflammatory sites by diverse cell types including monocytes/macrophages, endothelial cells, vascular smooth muscle cells, fibroblasts, and adipocytes. It plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. PTX3 particularly functions as a soluble pathogen recognition receptor and confers resistance against pathogens. Studies indicate that the protein removes apoptotic cells during immune responses. It associates with complement factor H, which is a complement regulator protein.
Physical form
1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, and 1 mM DTT.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
¿Ya tiene este producto?
Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Simone Bastrup-Birk et al.
PloS one, 8(9), e73119-e73119 (2013-09-17)
The long pentraxin-3 (PTX3) is a key component of the humoral arm of the innate immune system. PTX3 is produced locally in response to pro-inflammatory stimuli. To investigate PTX3 levels and its use as a biomarker in patients with systemic
Pentraxin-3 and the right ventricle: the Multi-Ethnic Study of Atherosclerosis?Right Ventricle Study
Peter Leary
Pulmonary Circulation, 4.2 (2014)
Bongkun Choi et al.
Oncotarget, 5(2), 481-492 (2014-01-25)
Pentraxin 3 (PTX3), a modulator of tumor-associated inflammation, is known to be positively correlated with tumor grade and severity of malignancies, but its exact role remains unclear. This study found that PTX3 expression was up-regulated in distant bone metastases of
Tunicamycin-induced Endoplasmic Reticulum Stress Upregulates the Expression of Pentraxin 3 in Human Retinal Pigment Epithelial Cells
Narae Hwang
Korean Journal of Ophthalmology : KJO, 30(6), 468-478 (2016)
Darrell Pilling et al.
PloS one, 10(3), e0119709-e0119709 (2015-03-17)
Monocyte-derived, fibroblast-like cells called fibrocytes are associated with fibrotic lesions. The plasma protein serum amyloid P component (SAP; also known as pentraxin-2, PTX2) inhibits fibrocyte differentiation in vitro, and injections of SAP inhibit fibrosis in vivo. SAP is a member
Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.
Póngase en contacto con el Servicio técnico