SML2731

alpha-NETA

≥98% (HPLC)

• Sinónimos: α-NETA, 2-(alpha-Naphthoyl)ethyltrimethylammonium iodide, N,N,N-Trimethyl-γ-oxo-1-naphthalenepropanaminium iodide, N,N,N-Trimethyl-3-(naphthalen-1-yl)-3-oxopropan-1-aminium iodide, a-NETA
• Fórmula empírica (notación de Hill): C₁₆H₂₀INO
• Número de CAS: 115066-04-1
• Peso molecular: 369.24
• Número MDL: MFCD00209857
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• condiciones de almacenamiento: desiccated
• color: white to beige
• solubilidad: DMSO: 2 mg/mL, clear
• temp. de almacenamiento: 2-8°C
• cadena SMILES: O=C(C1=CC=CC2=C1C=CC=C2)CC[N+](C)(C)C.[I-]
• InChI: 1S/C16H20NO.HI/c1-17(2,3)12-11-16(18)15-10-6-8-13-7-4-5-9-14(13)15;/h4-10H,11-12H2,1-3H3;1H/q+1;/p-1
• Clave InChI: QZXMJYVXMZJOAO-UHFFFAOYSA-M

Descripción

Acciones bioquímicas o fisiológicas

Originally identified as a substrate (ChA or choline)-noncompetitive, slowly reversible choline acetyltransferase inhibitor (human ChAT/BuChE/AChE IC₅₀ = 88 nM/33.3 μM/48.6 μM; does not affect mAChRs, AChE, ChE, CrAT, ganglionic or skeletal muscular nAChRs), α-NETA is a fluorescent molecule (Ex 255 & 297 nm; Em 427 nm) also known for its trace amine-associated receptor 5 (TAAR5 EC₅₀ = 150 nM) agonist and chemokine-like receptor-1 antagonist (IC₅₀ = 375 nM; 7 nM chemerin-induced CMKLR1 β-ARR2 recruitment) potencies both in cultures and in animal disease models in vivo (3-20 mg/kg via ip. or sc. in rats & mice).

Potent ChAT inhibitor, TAAR5 agonist, CMKLR1 (ChemR23) antagonist with in vivo efficacies in animal disease models.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable