SAB4301658

Anti-CSPG4 Antibody

rabbit polyclonal

• Sinónimos: HMW-MAA, MCSP, MCSPG, MSK16, NG2
• UNSPSC Code: 12352203
• NACRES: NA.41

Propiedades

• product name: Anti-CSPG4, affinity isolated antibody
• biological source: rabbit
• Quality Level: 100
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous glycerol solution
• species reactivity: human, mouse, rat
• technique(s): immunohistochemistry: 1:20-1:100; western blot: 1:500-1:2000
• accession no.: NP_001888
• UniProt accession no.: Q6UVK1
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... CSPG4(1464)

Descripción

General description

Chondroitin sulfate proteoglycan 4 (CSPG4) is commonly known as Melanoma chondroitin sulphate proteoglycan (MCSP). MCSP is a transmembrane protein. MCSP is lower in normal melanocytes. In human chromosome, the gene CSPG4 is localized on 15q24.2.

Immunogen

Synthetic peptide corresponding to residues near the C terminal of human chondroitin sulfate proteoglycan 4

Biochem/physiol Actions

Chondroitin sulfate proteoglycan 4 (CSPG4) is a cell surface antigen, expressed in most human melanoma and is crucial for tumour progression and invasion. MCSP activates cell division control protein 42 homolog (Cdc42) and Cdc42-associated tyrosine kinase-1 (Ack-1) to form complex, which signals and leads to melanoma progression and metastasis. The complex of MCSP with membrane-type 3 matrix metalloproteinase (MT3-MMP) signals melanoma invasion and proteolysis. MCSP is associated with angiogenesis dependent processes like tumor growth and healing of wound. MCSP plays a key role in regulating chondrosarcoma and provides resistance to chemotherapy. CSPG4 is a prognostic marker for glioblastoma.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable