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Merck
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SAB1305554

Sigma-Aldrich

Anti-β-Actin (ACTB) Antibody

mouse monoclonal, 137CT26.1.1

Sinónimos:

ACTB, Actin, cytoplasmic 1, Actin, cytoplasmic 1, N-terminally processed, Beta-actin

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

Nombre del producto

MONOCLONAL ANTI-BETA-ACTIN antibody produced in mouse, clone 137CT26.1.1, IgG fraction of antiserum, buffered aqueous solution

origen biológico

mouse

Nivel de calidad

100

forma del anticuerpo

IgG fraction of antiserum

tipo de anticuerpo

primary antibodies

clon

137CT26.1.1, monoclonal

Formulario

buffered aqueous solution

mol peso

41737 Da

reactividad de especies

mouse, human

técnicas

immunofluorescence: 1:10-1:50
immunohistochemistry: 1:25
western blot: 1:1000

isotipo

IgG1κ

Nº de acceso NCBI

NP_001092.1

Nº de acceso UniProt

P60709

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... ACTB(60)

Descripción general

β-actin (ACTB), a member of the actin multigene family, is an isoform of actin-associated with non-muscle cells. ACTB is a housekeeping gene mapped to human chromosome 7p22.1.

Aplicación

Monoclonal Anti-Beta-Actin antibody produced in mouse has been used in western blotting at a dilution of 1:1000.

Acciones bioquímicas o fisiológicas

β-actin (ACTB) forms the core of the cell cytoskeleton. The polymerization of β-actin is essential for cell physiology. It may serve as a potential chemotherapeutic agent. Mutation in the ACTB gene is implicated in sensory hearing loss, delayed-onset generalized dystonia and a combination of ventral midline malformations. A loss-of-function mutation in the ACTB gene may cause intellectual disability.

Forma física

Supplied in PBS with 0.09% (W/V) sodium azide

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
SG100806AD

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Sequence and structural analysis of beta-actin protein of fishes, using bioinformatics tools and techniques
Acharya UR, et al.
International journal of biosciences, 4(11) (2014)
Immacolata Andolfo et al.
Blood advances, 7(12), 2681-2693 (2023-01-04)
Gain-of-function mutations in PIEZO1 cause dehydrated hereditary stomatocytosis (DHS) or hereditary xerocytosis, an autosomal dominant hemolytic anemia characterized by high reticulocyte count, a tendency to macrocytosis, and mild jaundice, as well as by other variably penetrant clinical features, such as
Gaëlle Rached et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 10(6), e2204846-e2204846 (2023-01-17)
Insulin release is tightly controlled by glucose-stimulated calcium (GSCa) through hitherto equivocal pathways. This study investigates TRPC3, a non-selective cation channel, as a critical regulator of insulin secretion and glucose control. TRPC3's involvement in glucose-stimulated insulin secretion (GSIS) is studied
Christine Deisl et al.
The Journal of general physiology, 155(10) (2023-08-09)
Using optical and electrical methods, we document that diffusion in the cytoplasm of BL6 murine cardiomyocytes becomes restricted >20-fold as molecular weight increases from 30 to 2,000, roughly as expected for pores with porin channel dimensions. Bodipy-FL ATP diffuses >40-fold
Vincent Procaccio et al.
American journal of human genetics, 78(6), 947-960 (2006-05-11)
Actin, one of the major filamentous cytoskeletal molecules, is involved in a variety of cellular functions. Whereas an association between muscle actin mutations and skeletal and cardiac myopathies has been well documented, reports of human disease arising from mutations of
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