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Merck

S8197

Sigma-Aldrich

SMER28

>99% (HPLC), solid

Sinónimos:

6-bromo-N-2-propenyl-4-quinazolinamine

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About This Item

Fórmula empírica (notación de Hill):
C11H10BrN3
Número de CAS:
Peso molecular:
264.12
Número MDL:
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
NACRES:
NA.77

Nivel de calidad

Ensayo

>99% (HPLC)

Formulario

solid

solubilidad

DMSO: >20 mg/mL
H2O: insoluble

temp. de almacenamiento

2-8°C

cadena SMILES

Brc1ccc2ncnc(NCC=C)c2c1

InChI

1S/C11H10BrN3/c1-2-5-13-11-9-6-8(12)3-4-10(9)14-7-15-11/h2-4,6-7H,1,5H2,(H,13,14,15)

Clave InChI

BCPOLXUSCUFDGE-UHFFFAOYSA-N

Aplicación

SMER28 may be used in mTOR-mediated signaling studies.

Acciones bioquímicas o fisiológicas

SMER28 is a small molecule modulator of mammalian autophagy.
SMER28 is a small molecule modulator of mammalian autophagy; enhances A53T alpha-synuclein clearance in PC-12 cells independent of rapamycin treatment; appears to act independent of the mTOR pathway, but combined treatment with saturating rapamycin concentration enhances the effect of either compound alone on A53T alpha-synuclein clearance; autophagy inducers may prove useful in the treatment of neurodegenerative and infectious diseases and cancer.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves


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Ann K Rosenthal et al.
The Journal of biological chemistry, 290(21), 13028-13038 (2015-04-15)
Chondrocyte-derived extracellular organelles known as articular cartilage vesicles (ACVs) participate in non-classical protein secretion, intercellular communication, and pathologic calcification. Factors affecting ACV formation and release remain poorly characterized; although in some cell types, the generation of extracellular vesicles is associated
Dee Shen et al.
Cell biochemistry and biophysics, 60(3), 173-185 (2010-12-07)
Aggresomes and related inclusion bodies appear to serve as storage depots for misfolded and aggregated proteins within cells, which can potentially be degraded by the autophagy pathway. A homogenous fluorescence-based assay was devised to detect aggregated proteins inside aggresomes and
Prashant Bharadwaj et al.
Neural regeneration research, 15(10), 1931-1936 (2020-04-05)
Multiple lines of evidence show that soluble oligomer forms of amyloid β protein (Aβ42) are the most neurotoxic species in the brain and correlates with the degree of neuronal loss and cognitive deficit in Alzheimer's disease. Although many studies have
Yu Wu et al.
The FEBS journal, 287(15), 3184-3199 (2020-01-05)
The endo-lysosome system is involved in endocytosis, protein sorting, and degradation as well as autophagy. Numerous toxins and pathogens exploit this system to enter host cells and exert their deleterious effects. Modulation of host endo-lysosome pathway may restrict multiple toxins

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