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Merck

RAB0711

Sigma-Aldrich

Human CSF1R / Macrophage Colony-stimulating Factor 1 Receptor ELISA Kit

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About This Item

UNSPSC Code:
41116158
NACRES:
NA.84

species reactivity

human

packaging

kit of 96 wells (12 strips x 8 wells)

technique(s)

ELISA: suitable

assay range

inter-assay cv: <10%
intra-assay cv: <12%

detection method

colorimetric

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... CSF1R(1436)

General description

CSF1R (colony stimulating factor 1 receptor) is a member of the platelet-derived growth factor (PDGF) family of proteins and is a type III RTK (receptor tyrosine kinase). CSF1R is composed of five immunoglobulin (Ig)-like domains, a transmembrane region, a juxtamembrane domain and kinase insert domain (KID) intersecting the kinase domain.
The antibody pair provided in this kit recognizes human Macrophage Colony-stimulating Factor 1 Receptor.

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

Biochem/physiol Actions

CSF1R (colony stimulating factor 1 receptor) acts as a receptor for CSF1 and regulates monocyte and macrophage functioning. The protein and its ligand are linked to poor prognosis in patients with solid tumors and in patients with female reproductive cancers. In breast cancers, with decreased claudin levels, this protein regulates the switch between proliferative and invasive state of the tumor, acting downstream of TGFβ (tumor growth factor β). Haploinsufficiency in this receptor might lead to aberration of microglial function, which might be a contributor to the pathogenesis of hereditary diffuse leukoencephalopathy with spheroids (HDLS).

Los componentes del kit también están disponibles por separado

Referencia del producto
Descripción
SDS

  • RABTMB3ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)SDS

  • RABSTOP3ELISA Stop Solution (Item I)SDS

  • RABWASH420X Wash Buffer (Item B)SDS

pictograms

Corrosion

signalword

Warning

hcodes

Hazard Classifications

Met. Corr. 1

Storage Class

8A - Combustible corrosive hazardous materials

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Meghan Travers et al.
Cancer research, 79(13), 3445-3454 (2019-05-16)
Although ovarian cancer has a low incidence rate, it remains the most deadly gynecologic malignancy. Previous work has demonstrated that the DNMTi 5-Azacytidine (5AZA-C) activates type I interferon signaling to increase IFNγ+ T cells and natural killer (NK) cells and
Haploinsufficiency of CSF-1R and clinicopathologic characterization in patients with HDLS.
Konno T, et al.
Neurology, 10-1212 (2013)
Marta Banchi et al.
American journal of cancer research, 10(7), 2120-2127 (2020-08-11)
Anaplastic thyroid cancer (ATC) is the most aggressive form of thyroid cancer, and novel combined therapies are urgently needed to prolong patient survival. No data are currently available on the preclinical activity of the combination of linifanib, a CSF-1R inhibitor
Audrey C Knight et al.
Journal of neuropathology and experimental neurology, 77(3), 199-206 (2018-01-11)
Chronic microglial activation and associated neuroinflammation are key factors in neurodegenerative diseases including HIV-associated neurocognitive disorders. Colony stimulating factor 1 receptor (CSF1R)-mediated signaling is constitutive in cells of the myeloid lineage, including microglia, promoting cell survival, proliferation, and differentiation. In
Clare Pridans et al.
Scientific reports, 3, 3013-3013 (2013-10-23)
Hereditary diffuse leukoencephalopathy with spheroids (HDLS) in humans is a rare autosomal dominant disease characterized by giant neuroaxonal swellings (spheroids) within the CNS white matter. Symptoms are variable and can include personality and behavioural changes. Patients with this disease have

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