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Key Documents

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PZ0143

Sigma-Aldrich

PF-4708671

≥98% (HPLC)

Sinónimos:

2-((4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl)methyl)-5-(trifluoromethyl)-1H-benzo[d]imidazole

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About This Item

Fórmula empírica (notación de Hill):
C19H21F3N6
Número de CAS:
1255517-76-0
Peso molecular:
390.41
MDL number:
MFCD18086922
UNSPSC Code:
51111800
PubChem Substance ID:
329823728
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

off-white

solubility

DMSO: ≥20 mg/mL

storage temp.

room temp

SMILES string

CCC(C=NC=N1)=C1N2CCN(CC3=NC4=C(C=CC(C(F)(F)F)=C4)N3)CC2

InChI

1S/C19H21F3N6/c1-2-13-10-23-12-24-18(13)28-7-5-27(6-8-28)11-17-25-15-4-3-14(19(20,21)22)9-16(15)26-17/h3-4,9-10,12H,2,5-8,11H2,1H3,(H,25,26)

InChI key

FBLPQCAQRNSVHB-UHFFFAOYSA-N

Gene Information

human ... RPS6KB1(6198)
mouse ... Rps6kb1(72508)
rat ... Rps6kb1(83840)

Biochem/physiol Actions

PF-4708671 is a selective p70 ribosomal S6 kinase (S6K1) inhibitor. PF-4708671 inhibits S6K1 with a Ki of 20 nM and IC50 of 160 nM, while having no effect on the closely related RSK and MSK kinases.

Features and Benefits

This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Lei Wang et al.
International journal of stem cells, 14(3), 341-350 (2021-04-29)
Approximately 15% of couples suffer from infertility worldwide, and male factors contribute to about 30% of total sterility cases. However, there is little progress in treatments due to the obscured understanding of underlying mechanisms. Recently microRNAs have emerged as a
Erika Ishihara et al.
Genes to cells : devoted to molecular & cellular mechanisms, 25(3), 197-214 (2020-01-29)
Cell competition is a biological process by which unfit cells are eliminated from "cell society." We previously showed that cultured mammalian epithelial Madin-Darby canine kidney (MDCK) cells expressing constitutively active YAP were eliminated by apical extrusion when surrounded by "normal"
Mohamed Moustafa-Kamal et al.
Cell reports, 33(1), 108230-108230 (2020-10-08)
mTOR is a serine/threonine kinase and a master regulator of cell growth and proliferation. Raptor, a scaffolding protein that recruits substrates to mTOR complex 1 (mTORC1), is known to be phosphorylated during mitosis, but the significance of this phosphorylation remains

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