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Key Documents

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P5084

Sigma-Aldrich

PTIO

Sinónimos:

2-Phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide

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About This Item

Fórmula empírica (notación de Hill):
C13H17N2O2
Número de CAS:
18390-00-6
Peso molecular:
233.29
MDL number:
MFCD00059929
UNSPSC Code:
12352200
PubChem Substance ID:
329820215
NACRES:
NA.32

form

powder

Quality Level

200

storage temp.

2-8°C

SMILES string

CC1(C)N([O])C(c2ccccc2)=[N+]([O-])C1(C)C

InChI

1S/C13H17N2O2/c1-12(2)13(3,4)15(17)11(14(12)16)10-8-6-5-7-9-10/h5-9H,1-4H3

InChI key

DYUUGILMVYJEHY-UHFFFAOYSA-N

Application

2-phenyl-4, 4, 5, 5,-tetramethylimidazoline-1-oxyl 3-oxide (PTIO) has been used as a nitric oxide (NO) scavenger.

Biochem/physiol Actions

2-phenyl-4, 4, 5, 5,-tetramethylimidazoline-1-oxyl 3-oxide (PTIOs) derivatives react with nitric oxide (NO) to yield the corresponding imino nitroxides (PTIs) and nitrogen dioxide (NO2).
A stable radical scavenger for nitric oxide; affects NO without affecting NO synthase; has significant inhibitory activity against NO biological actions.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Victoria P A Johnstone et al.
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Luca G Mariotti et al.
International journal of radiation biology, 88(10), 751-762 (2012-06-20)
To investigate the mechanisms regulating the pathways of the bystander transmission in vitro, focusing on the radiation-perturbed signalling (via Interleukine 6, IL-6) of the irradiated cells after exposure to low doses of different radiation types. An integrated 'systems radiation biology'
Nitric oxide is involved in methyl jasmonate-induced defense responses and secondary metabolism activities of Taxus cells.
Wang JW and Wu JY
Plant & Cell Physiology, 46(6), 923-930 (2005)
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